Presumed central nervous system whipple’s disease in a child: Case report

Tina Q. Tan, Hannes Vogel, Barry R. Tharp, Clark L. Carrol, Sheldon L. Kaplan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Whipple’s disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple’s disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple’s disease who responded to therapy with trimethoprim-sulfamethoxazole.

Original languageEnglish (US)
Pages (from-to)883-889
Number of pages7
JournalClinical Infectious Diseases
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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