Presynaptic modulation by somatostatin in the neostriatum

Violeta Gisselle Lopez-Huerta, Fatuel Tecuapetla, Jaime N. Guzman, Jose Bargas*, Elvira Galarraga

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Medium spiny projection neurons (MSNs) are the main neuronal population in the neostriatum. MSNs are inhibitory and GABAergic. MSNs connect with other MSNs via local axon collaterals that produce lateral inhibition, which is thought to select cell assemblies for motor action. MSNs also receive inhibitory inputs from GABAergic local interneurons. This work shows, through the use of the paired pulse protocol, that somatostatin (SST) acts presynaptically to regulate GABA release from the terminals interconnecting MSNs. This SST action is reversible and not mediated through the release of dopamine. It is blocked by the SST receptor (SSTR) antagonist ciclosomatostatin (cicloSST). In contrast, SST does not regulate inhibition coming from interneurons. Because, SST is released by a class of local interneuron, it is concluded that this neuron helps to regulate the selection of motor acts.

Original languageEnglish (US)
Pages (from-to)1452-1458
Number of pages7
JournalNeurochemical Research
Issue number8
StatePublished - Aug 2008


  • GABA
  • Medium spiny neurons
  • Neostriatum
  • Presynaptic inhibition
  • Somatostatin

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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