Abstract
Purpose: To investigate the association between pretransplant intra-arterial liver-directed therapy (IAT) for hepatocellular carcinoma (HCC) and hepatic arterial complications (HAC) in orthotopic liver transplantation (OLT) [namely hepatic artery thrombosis (HAT) and/or the need for hepatic arterial conduit]. Methods: A total of 175 HCC patients (mean age: 60 years) underwent IAT with either transarterial chemoembolization or yttrium-90 (90Y) transarterial radioembolization prior to OLT between 2003 and 2013. A matched control cohort of 159 HCC patients who underwent OLT without prior IAT was selected. Incidence of HAC in both cohorts was investigated. The categorical differences between both cohorts were calculated by chi-square test. Results: Among the 175 patients (chemoembolization, n = 82; radioembolization, n = 93), 8 (5%) required conduits due to HA disease (chemoembolization, n = 6; radioembolization, n = 2), 3 (2%) developed HAT (chemoembolization, n = 2; radioembolization, n = 1). Eleven of 175 patients (6.7%) had HAC. Of the 159 control patients, 6 (4%) needed conduits for HA disease and 3 (2%) developed HAT. Nine of 159 patients (5.7%) had HAC. Chi-square analysis between the IAT cohort and the control group yielded a p value of 0.810. When comparing chemoembolization to radioembolization, p = 0.076 (not significant at p < 0.05). Conclusion: Although aggressive pretransplant radioembolization and chemoembolization are both utilized in most liver transplant centers, neither appears to increase the risk of peri-transplant hepatic arterial complications in HCC patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-238 |
| Number of pages | 8 |
| Journal | CardioVascular and Interventional Radiology |
| Volume | 41 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2018 |
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Keywords
- Conduit
- Hepatic arterial thrombosis
- Intra-arterial therapies
- Orthotopic liver transplant
- RE)
- Transarterial chemoembolization (TACE)
- Transarterial radioembolization (TARE
- Yttrium-90 (Y, Y90)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
}
Pretransplant Intra-arterial Liver-Directed Therapy Does Not Increase the Risk of Hepatic Arterial Complications in Liver Transplantation : A Single-Center 10-Year Experience. / Kallini, Joseph R.; Gabr, Ahmed; Ali, Rehan; Abouchaleh, Nadine; Riaz, Ahsun; Baker, Talia; Kulik, Laura M; Caicedo, Juan C; Salem, Riad; Lewandowski, Robert J.
In: CardioVascular and Interventional Radiology, Vol. 41, No. 2, 01.02.2018, p. 231-238.Research output: Contribution to journal › Article
TY - JOUR
T1 - Pretransplant Intra-arterial Liver-Directed Therapy Does Not Increase the Risk of Hepatic Arterial Complications in Liver Transplantation
T2 - A Single-Center 10-Year Experience
AU - Kallini, Joseph R.
AU - Gabr, Ahmed
AU - Ali, Rehan
AU - Abouchaleh, Nadine
AU - Riaz, Ahsun
AU - Baker, Talia
AU - Kulik, Laura M
AU - Caicedo, Juan C
AU - Salem, Riad
AU - Lewandowski, Robert J
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Purpose: To investigate the association between pretransplant intra-arterial liver-directed therapy (IAT) for hepatocellular carcinoma (HCC) and hepatic arterial complications (HAC) in orthotopic liver transplantation (OLT) [namely hepatic artery thrombosis (HAT) and/or the need for hepatic arterial conduit]. Methods: A total of 175 HCC patients (mean age: 60 years) underwent IAT with either transarterial chemoembolization or yttrium-90 (90Y) transarterial radioembolization prior to OLT between 2003 and 2013. A matched control cohort of 159 HCC patients who underwent OLT without prior IAT was selected. Incidence of HAC in both cohorts was investigated. The categorical differences between both cohorts were calculated by chi-square test. Results: Among the 175 patients (chemoembolization, n = 82; radioembolization, n = 93), 8 (5%) required conduits due to HA disease (chemoembolization, n = 6; radioembolization, n = 2), 3 (2%) developed HAT (chemoembolization, n = 2; radioembolization, n = 1). Eleven of 175 patients (6.7%) had HAC. Of the 159 control patients, 6 (4%) needed conduits for HA disease and 3 (2%) developed HAT. Nine of 159 patients (5.7%) had HAC. Chi-square analysis between the IAT cohort and the control group yielded a p value of 0.810. When comparing chemoembolization to radioembolization, p = 0.076 (not significant at p < 0.05). Conclusion: Although aggressive pretransplant radioembolization and chemoembolization are both utilized in most liver transplant centers, neither appears to increase the risk of peri-transplant hepatic arterial complications in HCC patients.
AB - Purpose: To investigate the association between pretransplant intra-arterial liver-directed therapy (IAT) for hepatocellular carcinoma (HCC) and hepatic arterial complications (HAC) in orthotopic liver transplantation (OLT) [namely hepatic artery thrombosis (HAT) and/or the need for hepatic arterial conduit]. Methods: A total of 175 HCC patients (mean age: 60 years) underwent IAT with either transarterial chemoembolization or yttrium-90 (90Y) transarterial radioembolization prior to OLT between 2003 and 2013. A matched control cohort of 159 HCC patients who underwent OLT without prior IAT was selected. Incidence of HAC in both cohorts was investigated. The categorical differences between both cohorts were calculated by chi-square test. Results: Among the 175 patients (chemoembolization, n = 82; radioembolization, n = 93), 8 (5%) required conduits due to HA disease (chemoembolization, n = 6; radioembolization, n = 2), 3 (2%) developed HAT (chemoembolization, n = 2; radioembolization, n = 1). Eleven of 175 patients (6.7%) had HAC. Of the 159 control patients, 6 (4%) needed conduits for HA disease and 3 (2%) developed HAT. Nine of 159 patients (5.7%) had HAC. Chi-square analysis between the IAT cohort and the control group yielded a p value of 0.810. When comparing chemoembolization to radioembolization, p = 0.076 (not significant at p < 0.05). Conclusion: Although aggressive pretransplant radioembolization and chemoembolization are both utilized in most liver transplant centers, neither appears to increase the risk of peri-transplant hepatic arterial complications in HCC patients.
KW - Conduit
KW - Hepatic arterial thrombosis
KW - Intra-arterial therapies
KW - Orthotopic liver transplant
KW - RE)
KW - Transarterial chemoembolization (TACE)
KW - Transarterial radioembolization (TARE
KW - Yttrium-90 (Y, Y90)
UR - http://www.scopus.com/inward/record.url?scp=85029173295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029173295&partnerID=8YFLogxK
U2 - 10.1007/s00270-017-1793-z
DO - 10.1007/s00270-017-1793-z
M3 - Article
C2 - 28900709
AN - SCOPUS:85029173295
VL - 41
SP - 231
EP - 238
JO - CardioVascular and Interventional Radiology
JF - CardioVascular and Interventional Radiology
SN - 7415-5101
IS - 2
ER -