Pretreatment of high-risk patients requiring radiographic contrast media studies

Paul A. Greenberger*, Roy Patterson, Ronald Simon, Philip Lieberman, Warren Wallace

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Pretreatment for 318 radiographic contrast media procedures in 284 patients with a prior anaphylactoid reaction to radiographic contrast media was associated with no adverse effects in 294 (92.5%) procedures. In 23 procedures (7.1%), mild or minimal reactions occurred that were of little or no consequence to the patient. One (0.3%) patient experienced transient hypotension, wheezing, and urticaria. The pretreatment program consisted of prednisone 50 mg orally every 6 hr for three doses ending 1 hr before the procedure and diphenhydramine 50 mg intramuscularly 1 hr before the procedure. Based on the cumulative results in the prospective series of 318 procedures, this regimen is appropriate prophylaxis for high-risk patients.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalThe Journal of allergy and clinical immunology
Issue number3
StatePublished - Mar 1981

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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