Pretreatment for 318 radiographic contrast media procedures in 284 patients with a prior anaphylactoid reaction to radiographic contrast media was associated with no adverse effects in 294 (92.5%) procedures. In 23 procedures (7.1%), mild or minimal reactions occurred that were of little or no consequence to the patient. One (0.3%) patient experienced transient hypotension, wheezing, and urticaria. The pretreatment program consisted of prednisone 50 mg orally every 6 hr for three doses ending 1 hr before the procedure and diphenhydramine 50 mg intramuscularly 1 hr before the procedure. Based on the cumulative results in the prospective series of 318 procedures, this regimen is appropriate prophylaxis for high-risk patients.
ASJC Scopus subject areas
- Immunology and Allergy