Abstract
Disorders of mineral metabolism develop early in chronic kidney disease, but it appears that Blacks with stage-5 disease have more severe secondary hyperparathyroidism than other races. We measured levels of parathyroid hormone, calcium, phosphorus, 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D) in 227 Black and 1633 non-Black participants in the SEEK study, a multi-center cohort of patients with early chronic kidney disease. Overall, Blacks had similar 1,25D levels compared with non-Blacks, but significantly lower levels of 25D with higher levels of calcium, phosphorus, and parathyroid hormone, and were significantly more likely to have hyperphosphatemia than non-Blacks. In multivariable analyses adjusted for age, gender, estimated glomerular filtration rate, body mass index, and diabetes, Blacks had significantly lower 25D and higher parathyroid hormone levels than non-Blacks, with the latter parameter remaining significant after further adjustment for calcium, phosphorus, 25D, and 1,25D. The association between Black race and secondary hyperparathyroidism, independent of known risk factors, suggests that novel mechanisms contribute to secondary hyperparathyroidism in Blacks with chronic kidney disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 956-962 |
| Number of pages | 7 |
| Journal | Kidney international |
| Volume | 73 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 2008 |
Funding
Funding for the original study and its data collection were supported by a grant from Abbott Laboratories. For this study, all of the hypotheses and analyses were generated and tested by the authors independent of industry support. We acknowledge the work of the SEEK Advisory Panel: Drs Dennis L Andress, George L Bakris, Adeera Levin, and Mark Molitch; and the SEEK investigators: Drs Allen Adolphe, Iftikhar Ahmad, Michael Alexander, Diego X Alvarez, Gustavo A Alza, Dennis Andress, James Andrews, Abraham Areephanthu, Carlos R Arguello, Carl Augustus, Dwight L Bailey, Ronald E Ballek, Ernesto E Banalagay, Saad E Bedeir, Andrew J Behnke, Sabrina Benjamin, Marializa V Bernardo, Jayantilal Bhimani, Edward Braun, Bernard Buchanan, Mary Carol Greenlee, Laurence Carroll, Chaim Charytan, Indira Chervu, William H Cleveland, Lou Constan, Deena Craig, James Cuellar, Albert M Defabritus, Amar Desai, Rajnish Dhingra, Douglass Domoto, Michael W Early Sr, Andrew E Edin, David Evanko, Stephen Fadem, Timothy Fagan, Michael Fedak, Bradford T Flagg, Brad Frandsen, Jeffery Freesemann, Linda Freilich, Stuart Friedman, Susan Fullemann, Dinesh R Gandhi, Steven R Ginos, Daniel Goodman, Burk Gossom, Catherine Grellet, Stephanie Gunnoe, Roger J Haley, Rekha D Halligan, Daniel Halm, Maxine E Hamilton, Laila C Hanna, Merfat Hassan, George Herron, Peck P Hsu, Yiling Huang, Scott Isaacs, Shah Islam, Peter Jacobson, Albert F Johary, Ronald W Johnson, Alan Jones, Regi Joseph, Lionel B Katchem, Bruce A Kauk, Rebecca Knight, David Koeper, Lawrence Kramer, Gerald Kumin, Stella S Kwong, David Lahasky, Vinodrai Lakhani, Rachel Langland, Chok Lee, Irene Leech, Daniel J Legault, Lawrence Lehrner, April Liverman, James Love, Joshua Lowentritt, Blanca Luna, Michael Macadams, Isam Marar, Eric Marcotte, Steven Margolis, Eric Marshall, Carlos O Martinez, Janus Maybee, Gela Mchedlishvili, Donald J Meyer, Kenneth Miller, James Miller Oppy, Palghat V Mohan, Ramakant Mulay, Derek Muse, Rhonda I Museums, Kent W Myers, Seymour Myers, Arif Nazir, Patrick Ogilvie, Kevin W Ohara, Paul Pagnozzi, Meyappan Palaniappan, Saradha Perinbasekar, Marvin Pietruszka, George E Platt, John H Poehlman, Peterman Prosser, Alan D Purdy, Gary Raffel, David Ramstad, Harvey Resnick, Wayne Reynolds, Louis Reznick, Matt Rosenberg, Paul Rosenblit, Roset N Samuel, Rallabhandi Sankaram, Deepak Santram, Neil Schwartzman, Peter Scuccimarri, Gladstone Sellers, Chandrakant Shah, Jeffery G Shanes, Devendra K Sharma, Michael Scheaffer, Raewyn Shell, Terry Sherraden, Anil Sheth, Thomas Shetter, Phillip Shou, Haven Silver, George A Smith, Karen L Smith, Donna Steadman, Helen Story, David C Subich, Robert M Taxin, Gary Tigges, Robert W Tom, Thomas Tse, Umamaheswara Vejendla, Samuel Verzosa, William C Ware, Robert Weiss, Lindsey White, Richard Woronoff, Alberto Yataco, Raja Zabaneh, Mayer Zayan. This study was supported by an American Kidney Fund Clinical Scientist in Nephrology Fellowship (OMG) and grants K30RR02229207, K23RR017376 (MW), and RO1DK076116 (MW) from the National Institutes of Health.
Keywords
- Chronic kidney disease
- Mineral metabolism
- Racial disparities
ASJC Scopus subject areas
- Nephrology
