TY - JOUR
T1 - Prevalence, incidence, and persistence of psychiatric and substance use disorders among mothers living with HIV
AU - Malee, Kathleen M.
AU - Mellins, Claude A.
AU - Huo, Yanling
AU - Tassiopoulos, Katherine
AU - Smith, Renee
AU - Sirois, Patricia A.
AU - Allison, Susannah M.
AU - Kacanek, Deborah
AU - Kapetanovic, Suad
AU - Williams, Paige L.
AU - Grant, Mitzie L.
AU - Marullo, Daniel
AU - Aidala, Angela A.
PY - 2014/4/15
Y1 - 2014/4/15
N2 - Objective: To evaluate prevalence, incidence, remission, and persistence of psychiatric and substance use disorders among HIVinfected mothers and identify biopsychosocial correlates. Methods: HIV-infected mothers (n = 1223) of HIV-exposed uninfected children enrolled in a prospective cohort study; HIVuninfected mothers (n = 128) served as a comparison group. Mothers provided sociodemographic and health information and completed the Client Diagnostic Questionnaire (CDQ). Prevalence of any psychiatric or substance use disorder at initial evaluation was compared between the 2 groups. Incident, remitting, and persisting disorders were identified for 689 mothers with HIV who completed follow-up CDQs. We used logistic regression to evaluate adjusted associations of biopsychosocial characteristics with presence, incidence, remission, and persistence of disorders. Results: Thirty-five percent of mothers screened positive for any psychiatric or substance use disorder at initial evaluation, with no difference by maternal HIV status (P = 1.00). Among HIV-infected mothers, presence of any disorder was associated with younger age [adjusted odds ratio (aOR): 1.39; 95% CI: 1.09 to 1.75], single parenthood (aOR: 1.35; 95% CI: 1.08 to 1.68), and functional limitations (aOR: 2.29; 95% CI: 1.81 to 2.90). Incident disorders were associated with functional limitations (aOR: 1.92; 95% CI: 1.10 to 3.30). Among HIV-infected mothers with a disorder at initial evaluation (n = 238), 61% had persistent disorders. Persistent disorders were associated with lower income (aOR: 2.44; 95% CI: 1.33 to 4.76) and functional limitations (aOR: 3.19; 95% CI: 1.87 to 5.48). Receipt of treatment for any disorder was limited: 4.5% at study entry, 7% at follow-up, 5.5% at both entry and follow-up. Conclusions: Psychiatric and substance use disorders remain significant comorbid conditions among HIV-infected mothers and require accessible evidence-informed treatment.
AB - Objective: To evaluate prevalence, incidence, remission, and persistence of psychiatric and substance use disorders among HIVinfected mothers and identify biopsychosocial correlates. Methods: HIV-infected mothers (n = 1223) of HIV-exposed uninfected children enrolled in a prospective cohort study; HIVuninfected mothers (n = 128) served as a comparison group. Mothers provided sociodemographic and health information and completed the Client Diagnostic Questionnaire (CDQ). Prevalence of any psychiatric or substance use disorder at initial evaluation was compared between the 2 groups. Incident, remitting, and persisting disorders were identified for 689 mothers with HIV who completed follow-up CDQs. We used logistic regression to evaluate adjusted associations of biopsychosocial characteristics with presence, incidence, remission, and persistence of disorders. Results: Thirty-five percent of mothers screened positive for any psychiatric or substance use disorder at initial evaluation, with no difference by maternal HIV status (P = 1.00). Among HIV-infected mothers, presence of any disorder was associated with younger age [adjusted odds ratio (aOR): 1.39; 95% CI: 1.09 to 1.75], single parenthood (aOR: 1.35; 95% CI: 1.08 to 1.68), and functional limitations (aOR: 2.29; 95% CI: 1.81 to 2.90). Incident disorders were associated with functional limitations (aOR: 1.92; 95% CI: 1.10 to 3.30). Among HIV-infected mothers with a disorder at initial evaluation (n = 238), 61% had persistent disorders. Persistent disorders were associated with lower income (aOR: 2.44; 95% CI: 1.33 to 4.76) and functional limitations (aOR: 3.19; 95% CI: 1.87 to 5.48). Receipt of treatment for any disorder was limited: 4.5% at study entry, 7% at follow-up, 5.5% at both entry and follow-up. Conclusions: Psychiatric and substance use disorders remain significant comorbid conditions among HIV-infected mothers and require accessible evidence-informed treatment.
KW - HIV
KW - Prevalence
KW - Psychiatric disorder
KW - Substance use disorders
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=84898749277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898749277&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000000070
DO - 10.1097/QAI.0000000000000070
M3 - Article
C2 - 24759063
AN - SCOPUS:84898749277
SN - 1525-4135
VL - 65
SP - 526
EP - 534
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 5
ER -
