TY - JOUR
T1 - Prevalence of allergic rhinitis and asthma in patients with chronic rhinosinusitis and gastroesophageal reflux disease
AU - Mahdavinia, Mahboobeh
AU - Bishehsari, Faraz
AU - Hayat, Waqas
AU - Codispoti, Christopher D.
AU - Sarrafi, Shahram
AU - Husain, Inna
AU - Mehta, Arpita
AU - Benhammuda, Mohamed
AU - Tobin, Mary C.
AU - Bandi, Sindhura
AU - LoSavio, Philip S.
AU - Jeffe, Jill S.
AU - Palmisano, Erica L.
AU - Schleimer, Robert P.
AU - Batra, Pete S.
N1 - Funding Information:
Funding Sources: This study was entirely conducted by internal departmental funding by Rush University. Dr Mahdavinia is supported by a Cohn Scholarship from the Rush University mentoring office. Dr Bishehsari was supported by Rush Translational Sciences Consortium/Swim Across America and Rush University, Department of Medicine, Academic Mentoring Program Research Track Award. Dr Schleimer is supported in part by the Ernest S. Bazley Foundation, grant U19 AI106683 from the National Institute of Allergy and Infectious Diseases, and grant R37 HL068546 from the National Heart, Lung, and Blood Institute.
Publisher Copyright:
© 2016 American College of Allergy, Asthma & Immunology
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Background An association between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD) has been previously reported; however, the underlying factors linking CRS and GERD remain to be elucidated. Objective To assess the association of GERD and CRS using prospective and retrospective approaches. Methods The retrospective study comprised a large cohort of CRS cases, whereas the prospective arm evaluated a series of CRS cases and controls. Results In the retrospective arm of the study, of the 1066 patients with CRS, 112 (10.5%) had GERD. Among patients with CRS, GERD was associated with higher body mass index, older age, and female sex. The odds ratios (ORs) for asthma and allergic rhinitis in the CRS group with GERD compared with the CRS group without GERD were 2.89 (95% confidence interval [CI], 1.905–4.389) and 2.021 (95% CI, 1.035–3.947). Furthermore, GERD was associated with a greater duration of CRS. Ninety patients with CRS and 81 controls were enrolled in the prospective arm of the study. In the CRS group, GERD was associated with asthma (OR, 4.77; 95% CI, 1.27–18.01). Patients with CRS and GERD had a longer duration and a younger age at onset of CRS. In controls, no association was found between GERD and asthma (OR, 0.67; 95% CI, 0.09–5.19) or allergic rhinitis (OR, 0.35; 95% CI, 0.05–2.59). Conclusion Patients with CRS and GERD are more likely to have atopic conditions and asthma when compared with patients with CRS but without GERD. One of the potential explanations of this link is that comorbid GERD and atopic disease are potential risk factors for development of CRS.
AB - Background An association between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD) has been previously reported; however, the underlying factors linking CRS and GERD remain to be elucidated. Objective To assess the association of GERD and CRS using prospective and retrospective approaches. Methods The retrospective study comprised a large cohort of CRS cases, whereas the prospective arm evaluated a series of CRS cases and controls. Results In the retrospective arm of the study, of the 1066 patients with CRS, 112 (10.5%) had GERD. Among patients with CRS, GERD was associated with higher body mass index, older age, and female sex. The odds ratios (ORs) for asthma and allergic rhinitis in the CRS group with GERD compared with the CRS group without GERD were 2.89 (95% confidence interval [CI], 1.905–4.389) and 2.021 (95% CI, 1.035–3.947). Furthermore, GERD was associated with a greater duration of CRS. Ninety patients with CRS and 81 controls were enrolled in the prospective arm of the study. In the CRS group, GERD was associated with asthma (OR, 4.77; 95% CI, 1.27–18.01). Patients with CRS and GERD had a longer duration and a younger age at onset of CRS. In controls, no association was found between GERD and asthma (OR, 0.67; 95% CI, 0.09–5.19) or allergic rhinitis (OR, 0.35; 95% CI, 0.05–2.59). Conclusion Patients with CRS and GERD are more likely to have atopic conditions and asthma when compared with patients with CRS but without GERD. One of the potential explanations of this link is that comorbid GERD and atopic disease are potential risk factors for development of CRS.
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U2 - 10.1016/j.anai.2016.05.018
DO - 10.1016/j.anai.2016.05.018
M3 - Article
C2 - 27283453
AN - SCOPUS:84973579527
SN - 1081-1206
VL - 117
SP - 158-162.e1
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 2
ER -