Prevalence of cervical HPV infection, sexually transmitted infections and associated antimicrobial resistance in women attending cervical cancer screening in Mali

Aude Jary*, Ibrahima Teguete, Younoussa Sidibé, Amadou Kodio, Oumar Dolo, Sonia Burrel, David Boutolleau, Laurianne Beauvais-Remigereau, Sophie Sayon, Mamadou Kampo, Fatoumata Tata Traoré, Mariam Sylla, Chad Achenbach, Robert Murphy, Béatrice Berçot, Cécile Bébéar, Vincent Calvez, Anne Geneviève Marcelin, Almoustapha I. Maiga

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess the prevalence of sexually transmitted infections (STIs), antimicrobial resistance and cervical lesions among women from Sikasso, Mali. Methods: Women infected with human immunodeficiency virus (HIV) (n=44) and HIV-negative women (n=96) attending cervical cancer screening were included. Screening for human papillomavirus (HPV), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) was performed using polymerase chain reaction assays, and herpes simplex virus (HSV-1/2) serological status was assessed using enzyme-linked immunosorbent assays. Antibiotic resistance tests were performed for MG- and NG-positive cases. Results: A high prevalence of high-risk HPV (hrHPV) infection (63%) was found. This was associated with cervical lesions in 7.5% of cases. An unusual distribution was found, with HPV31, HPV56 and HPV52 being the most prevalent. The hrHPV distribution differed by HIV status, with HIV-positive cases having HPV35/31/51-52-56 and HIV-negative cases having HPV31/56/52. The seroprevalence of HSV-2 was 49%, and the prevalence of other STIs was as follows: CT, 4%; MG, 9%; NG, 1%; and TV, 7%. Five of nine MG-positive specimens and the NG strains obtained were resistant to fluoroquinolone. Conclusions: These results showed high prevalence of hrHPV and fluoroquinolone resistance in several NG and MG strains. Further studies are required to confirm these data in Mali, and to improve prevention, screening and management of cervical cancer and other STIs in women.

Original languageEnglish (US)
Pages (from-to)610-616
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume108
DOIs
StatePublished - Jul 2021

Keywords

  • Antimicrobial resistance
  • Cervical lesions
  • HIV
  • HPV
  • Mali
  • STIs

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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