Abstract
Objectives: To assess the prevalence of sexually transmitted infections (STIs), antimicrobial resistance and cervical lesions among women from Sikasso, Mali. Methods: Women infected with human immunodeficiency virus (HIV) (n=44) and HIV-negative women (n=96) attending cervical cancer screening were included. Screening for human papillomavirus (HPV), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) was performed using polymerase chain reaction assays, and herpes simplex virus (HSV-1/2) serological status was assessed using enzyme-linked immunosorbent assays. Antibiotic resistance tests were performed for MG- and NG-positive cases. Results: A high prevalence of high-risk HPV (hrHPV) infection (63%) was found. This was associated with cervical lesions in 7.5% of cases. An unusual distribution was found, with HPV31, HPV56 and HPV52 being the most prevalent. The hrHPV distribution differed by HIV status, with HIV-positive cases having HPV35/31/51-52-56 and HIV-negative cases having HPV31/56/52. The seroprevalence of HSV-2 was 49%, and the prevalence of other STIs was as follows: CT, 4%; MG, 9%; NG, 1%; and TV, 7%. Five of nine MG-positive specimens and the NG strains obtained were resistant to fluoroquinolone. Conclusions: These results showed high prevalence of hrHPV and fluoroquinolone resistance in several NG and MG strains. Further studies are required to confirm these data in Mali, and to improve prevention, screening and management of cervical cancer and other STIs in women.
Original language | English (US) |
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Pages (from-to) | 610-616 |
Number of pages | 7 |
Journal | International Journal of Infectious Diseases |
Volume | 108 |
DOIs | |
State | Published - Jul 2021 |
Funding
The authors wish to thank Marie Gardette for technical assistance. This work was presented, in part (HPV data), as an oral communication at Eurogin, 4–7 December 2019, Monte-Carlo, Monaco. This work was funded by the Agence Nationale de Recherche sur le SIDA et les Hépatites Virales AC43 ‘Sexually Transmitted Infections’ Working Group and GSK France. This study was approved by the Comité d'Ethique Institutionnel de la Faculté de Médecine, de Pharmacie et d'Odontostomatologie, Université des Sciences Techniques et des Technologies de Bamako. Conception and design of the study: CA, RM, VC, AGM, AIM. Patient enrolment and acquisition of clinical data: IT, YS, AK, OD, MK, FTT, MS. Execution of experiments: SS. Data analysis: AJ, SB, DB, LBR, BB, CB. Drafting a significant portion of the manuscript or figures: AJ, IT, SB, DB, CB. All the authors read, corrected and approved the final manuscript. This work was funded by the Agence Nationale de Recherche sur le SIDA et les Hépatites Virales AC43 ‘Sexually Transmitted Infections’ Working Group and GSK France.
Keywords
- Antimicrobial resistance
- Cervical lesions
- HIV
- HPV
- Mali
- STIs
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases