Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study

The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group

doi:10.1002/nau.24613

Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study

The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Aims: To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). Methods: In this secondary analysis of the Lower Urinary Tract Research Network Observational Cohort Study, participants completed the LUTS tool, childhood trauma events scale (CTES), PROMIS depression and anxiety and perceived stress scale. LUTS tool responses were combined to quantify urinary urgency, frequency, incontinence, and overall LUTS severity. Multivariable linear regression tested associations between trauma and LUTS; mental health scores were tested for potential mediation. Results: In this cohort (n = 1011; 520 women, 491 men), more women reported experiencing at least one trauma (75% vs. 64%, p <.001), greater than three traumas (26% vs. 15%, p <.001), and childhood sexual trauma (23% vs. 7%, p <.001), and reported higher impact from traumatic events compared with men (median [interquartile rnage] CTES score = 10 [5–15] vs. 6 [4–12], p <.001). The number of childhood traumatic events was not associated with severity of overall LUTS (p =.79), urinary frequency (p =.75), urgency (p =.61), or incontinence (p =.21). Childhood sexual trauma was significantly associated with higher incontinence severity (adjusted mean difference 4.5 points, 95% confidence interval= 1.11–7.88, p =.009). Mental health was a mediator between trauma and LUTS among those with at least one childhood trauma. Conclusion: Although total childhood trauma is not associated with LUTS, childhood sexual trauma is associated with urinary incontinence severity. For patients with childhood trauma, half of the effect of CTE Impact score on overall LUTS severity is mediated through the association between trauma and the patient's mental health.

Original language	English (US)
Pages (from-to)	632-641
Number of pages	10
Journal	Neurourology and Urodynamics
Volume	40
Issue number	2
DOIs	https://doi.org/10.1002/nau.24613
State	Published - Feb 2021

Funding

Heather Van Doren, Senior Medical Editor with Arbor Research Collaborative for Health, provided editorial assistance on this manuscript. This is publication number 26 of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). This study is supported by the National Institute of Diabetes & Digestive & Kidney Diseases through cooperative agreements (grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, and DK099879). Research reported in this publication was supported at Northwestern University, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Keywords

childhood trauma
lower urinary tract symptoms
overactive bladder
posttraumatic stress disorder
urinary incontinence

ASJC Scopus subject areas

Clinical Neurology
Urology

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10.1002/nau.24613

Cite this

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title = "Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study",

abstract = "Aims: To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). Methods: In this secondary analysis of the Lower Urinary Tract Research Network Observational Cohort Study, participants completed the LUTS tool, childhood trauma events scale (CTES), PROMIS depression and anxiety and perceived stress scale. LUTS tool responses were combined to quantify urinary urgency, frequency, incontinence, and overall LUTS severity. Multivariable linear regression tested associations between trauma and LUTS; mental health scores were tested for potential mediation. Results: In this cohort (n = 1011; 520 women, 491 men), more women reported experiencing at least one trauma (75% vs. 64%, p <.001), greater than three traumas (26% vs. 15%, p <.001), and childhood sexual trauma (23% vs. 7%, p <.001), and reported higher impact from traumatic events compared with men (median [interquartile rnage] CTES score = 10 [5–15] vs. 6 [4–12], p <.001). The number of childhood traumatic events was not associated with severity of overall LUTS (p =.79), urinary frequency (p =.75), urgency (p =.61), or incontinence (p =.21). Childhood sexual trauma was significantly associated with higher incontinence severity (adjusted mean difference 4.5 points, 95% confidence interval= 1.11–7.88, p =.009). Mental health was a mediator between trauma and LUTS among those with at least one childhood trauma. Conclusion: Although total childhood trauma is not associated with LUTS, childhood sexual trauma is associated with urinary incontinence severity. For patients with childhood trauma, half of the effect of CTE Impact score on overall LUTS severity is mediated through the association between trauma and the patient's mental health.",

keywords = "childhood trauma, lower urinary tract symptoms, overactive bladder, posttraumatic stress disorder, urinary incontinence",

author = "{The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group} and Julia Geynisman-Tan and Margaret Helmuth and Smith, {Abigail R.} and Lai, {H. Henry} and Amundsen, {Cindy L.} and Bradley, {Catherine S.} and Mueller, {Margaret G} and Gaupp, {Christina Lewicky} and Harte, {Steven E.} and Jelovsek, {J. Eric}",

note = "Funding Information: Heather Van Doren, Senior Medical Editor with Arbor Research Collaborative for Health, provided editorial assistance on this manuscript. This is publication number 26 of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). This study is supported by the National Institute of Diabetes & Digestive & Kidney Diseases through cooperative agreements (grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, and DK099879). Research reported in this publication was supported at Northwestern University, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = feb,

doi = "10.1002/nau.24613",

language = "English (US)",

volume = "40",

pages = "632--641",

journal = "Neurourology and Urodynamics",

issn = "0733-2467",

publisher = "John Wiley and Sons Inc.",

number = "2",

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TY - JOUR

T1 - Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study

AU - The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group

AU - Geynisman-Tan, Julia

AU - Helmuth, Margaret

AU - Smith, Abigail R.

AU - Lai, H. Henry

AU - Amundsen, Cindy L.

AU - Bradley, Catherine S.

AU - Mueller, Margaret G

AU - Gaupp, Christina Lewicky

AU - Harte, Steven E.

AU - Jelovsek, J. Eric

N1 - Funding Information: Heather Van Doren, Senior Medical Editor with Arbor Research Collaborative for Health, provided editorial assistance on this manuscript. This is publication number 26 of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). This study is supported by the National Institute of Diabetes & Digestive & Kidney Diseases through cooperative agreements (grants DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, and DK099879). Research reported in this publication was supported at Northwestern University, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2021 Wiley Periodicals LLC

PY - 2021/2

Y1 - 2021/2

N2 - Aims: To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). Methods: In this secondary analysis of the Lower Urinary Tract Research Network Observational Cohort Study, participants completed the LUTS tool, childhood trauma events scale (CTES), PROMIS depression and anxiety and perceived stress scale. LUTS tool responses were combined to quantify urinary urgency, frequency, incontinence, and overall LUTS severity. Multivariable linear regression tested associations between trauma and LUTS; mental health scores were tested for potential mediation. Results: In this cohort (n = 1011; 520 women, 491 men), more women reported experiencing at least one trauma (75% vs. 64%, p <.001), greater than three traumas (26% vs. 15%, p <.001), and childhood sexual trauma (23% vs. 7%, p <.001), and reported higher impact from traumatic events compared with men (median [interquartile rnage] CTES score = 10 [5–15] vs. 6 [4–12], p <.001). The number of childhood traumatic events was not associated with severity of overall LUTS (p =.79), urinary frequency (p =.75), urgency (p =.61), or incontinence (p =.21). Childhood sexual trauma was significantly associated with higher incontinence severity (adjusted mean difference 4.5 points, 95% confidence interval= 1.11–7.88, p =.009). Mental health was a mediator between trauma and LUTS among those with at least one childhood trauma. Conclusion: Although total childhood trauma is not associated with LUTS, childhood sexual trauma is associated with urinary incontinence severity. For patients with childhood trauma, half of the effect of CTE Impact score on overall LUTS severity is mediated through the association between trauma and the patient's mental health.

AB - Aims: To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). Methods: In this secondary analysis of the Lower Urinary Tract Research Network Observational Cohort Study, participants completed the LUTS tool, childhood trauma events scale (CTES), PROMIS depression and anxiety and perceived stress scale. LUTS tool responses were combined to quantify urinary urgency, frequency, incontinence, and overall LUTS severity. Multivariable linear regression tested associations between trauma and LUTS; mental health scores were tested for potential mediation. Results: In this cohort (n = 1011; 520 women, 491 men), more women reported experiencing at least one trauma (75% vs. 64%, p <.001), greater than three traumas (26% vs. 15%, p <.001), and childhood sexual trauma (23% vs. 7%, p <.001), and reported higher impact from traumatic events compared with men (median [interquartile rnage] CTES score = 10 [5–15] vs. 6 [4–12], p <.001). The number of childhood traumatic events was not associated with severity of overall LUTS (p =.79), urinary frequency (p =.75), urgency (p =.61), or incontinence (p =.21). Childhood sexual trauma was significantly associated with higher incontinence severity (adjusted mean difference 4.5 points, 95% confidence interval= 1.11–7.88, p =.009). Mental health was a mediator between trauma and LUTS among those with at least one childhood trauma. Conclusion: Although total childhood trauma is not associated with LUTS, childhood sexual trauma is associated with urinary incontinence severity. For patients with childhood trauma, half of the effect of CTE Impact score on overall LUTS severity is mediated through the association between trauma and the patient's mental health.

KW - childhood trauma

KW - lower urinary tract symptoms

KW - overactive bladder

KW - posttraumatic stress disorder

KW - urinary incontinence

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ER -

Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study

Abstract

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