Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria

Francis Ajang Magaji; Mark Ojogba Okolo; Z. Hassan; Iornum H. Shambe; Victor Chung Pam; Amaka Ngozi Ocheke; Esther S. Yiltok; Williams Golit; Stephen Ajen Anzaku; Martins Daloek; Jerry Ogwuche; Godwin E. Imade; Christain Isichie; Jsiah T. Mutihir; Stephen Oguche; Oche Agbaji; Jonah Musa; Solomon Ateine Sagay; A. I. Zoakah; Susan E. Cohn

doi:10.4103/aam.aam_20_19

Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria

Francis Ajang Magaji^*, Mark Ojogba Okolo, Z. Hassan, Iornum H. Shambe, Victor Chung Pam, Amaka Ngozi Ocheke, Esther S. Yiltok, Williams Golit, Stephen Ajen Anzaku, Martins Daloek, Jerry Ogwuche, Godwin E. Imade, Christain Isichie, Jsiah T. Mutihir, Stephen Oguche, Oche Agbaji, Jonah Musa, Solomon Ateine Sagay, A. I. Zoakah, Susan E. Cohn

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

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Abstract

Objectives: The study sought to determine the prevalence and risk factors associated with Hepatitis B surface antigenemia (HBsAg) positivity among pregnant women in Jos, Nigeria. Methodology: This was a cross-sectional study carried out among the pregnant population in five healthcare facilities in Jos, between November 1, 2017 and April 30, 2018. Informed consent was obtained, and data on sociodemographic and risk factors for hepatitis B virus (HBV) infection were collected. Hepatitis B viral infection was assessed using the in vitro HBsAg diagnostic rapid kit (Acon Laboratories, USA). Descriptive statistics, Chi-square test, and logistic regression were performed to identify predictors of HBV infection in the study population. All statistical analyses were carried out on STATA version 15. Results: Of the 3,238 women enrolled, 7.4% (241/3238) (95% confidence interval [CI] = 6.6% to 8.4%) were HBsAg positive. The absence of HBV vaccination (adjusted odds ratio [AOR] = 2.49; 95% CI = 1.49-4.09; P < 0.001), co-infection with HIV (AOR = 1.90; 95% CI = 1.18-3.08; P = 0.009), and higher parity (AOR = 1.37; 95% CI = 1.04-1.79; P = 0.024) were independently associated with HBV infection in pregnancy. Conclusions: The prevalence of HBV infection among pregnant women was high, especially among those without prior vaccination for HBV, those with HIV co-infection and higher parity.

Original language	English (US)
Pages (from-to)	176-181
Number of pages	6
Journal	Annals of African Medicine
Volume	19
Issue number	3
DOIs	https://doi.org/10.4103/aam.aam_20_19
State	Published - Jul 1 2020

Funding

The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Office of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Offce of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the offcial views of the National Institutes of Health.

Keywords

Hepatitis-B virus infection
Nigeria
pregnancy
prevalence

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4103/aam.aam_20_19

Cite this

Magaji, F. A., Okolo, M. O., Hassan, Z., Shambe, I. H., Pam, V. C., Ocheke, A. N., Yiltok, E. S., Golit, W., Anzaku, S. A., Daloek, M., Ogwuche, J., Imade, G. E., Isichie, C., Mutihir, J. T., Oguche, S., Agbaji, O., Musa, J., Sagay, S. A., Zoakah, A. I., & Cohn, S. E. (2020). Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria. Annals of African Medicine, 19(3), 176-181. https://doi.org/10.4103/aam.aam_20_19

@article{23c3c6235b1342a6b28516e9e4b47e0a,

title = "Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria",

abstract = "Objectives: The study sought to determine the prevalence and risk factors associated with Hepatitis B surface antigenemia (HBsAg) positivity among pregnant women in Jos, Nigeria. Methodology: This was a cross-sectional study carried out among the pregnant population in five healthcare facilities in Jos, between November 1, 2017 and April 30, 2018. Informed consent was obtained, and data on sociodemographic and risk factors for hepatitis B virus (HBV) infection were collected. Hepatitis B viral infection was assessed using the in vitro HBsAg diagnostic rapid kit (Acon Laboratories, USA). Descriptive statistics, Chi-square test, and logistic regression were performed to identify predictors of HBV infection in the study population. All statistical analyses were carried out on STATA version 15. Results: Of the 3,238 women enrolled, 7.4% (241/3238) (95% confidence interval [CI] = 6.6% to 8.4%) were HBsAg positive. The absence of HBV vaccination (adjusted odds ratio [AOR] = 2.49; 95% CI = 1.49-4.09; P < 0.001), co-infection with HIV (AOR = 1.90; 95% CI = 1.18-3.08; P = 0.009), and higher parity (AOR = 1.37; 95% CI = 1.04-1.79; P = 0.024) were independently associated with HBV infection in pregnancy. Conclusions: The prevalence of HBV infection among pregnant women was high, especially among those without prior vaccination for HBV, those with HIV co-infection and higher parity.",

keywords = "Hepatitis-B virus infection, Nigeria, pregnancy, prevalence",

author = "Magaji, {Francis Ajang} and Okolo, {Mark Ojogba} and Z. Hassan and Shambe, {Iornum H.} and Pam, {Victor Chung} and Ocheke, {Amaka Ngozi} and Yiltok, {Esther S.} and Williams Golit and Anzaku, {Stephen Ajen} and Martins Daloek and Jerry Ogwuche and Imade, {Godwin E.} and Christain Isichie and Mutihir, {Jsiah T.} and Stephen Oguche and Oche Agbaji and Jonah Musa and Sagay, {Solomon Ateine} and Zoakah, {A. I.} and Cohn, {Susan E.}",

note = "Funding Information: The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Office of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Offce of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the offcial views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2020 Annals of African Medicine Published by Wolters Kluwer-Medknow.",

year = "2020",

month = jul,

day = "1",

doi = "10.4103/aam.aam_20_19",

language = "English (US)",

volume = "19",

pages = "176--181",

journal = "Annals of African Medicine",

issn = "1596-3519",

publisher = "Wolters Kluwer Medknow Publications",

number = "3",

}

Magaji, FA, Okolo, MO, Hassan, Z, Shambe, IH, Pam, VC, Ocheke, AN, Yiltok, ES, Golit, W, Anzaku, SA, Daloek, M, Ogwuche, J, Imade, GE, Isichie, C, Mutihir, JT, Oguche, S, Agbaji, O, Musa, J, Sagay, SA, Zoakah, AI & Cohn, SE 2020, 'Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria', Annals of African Medicine, vol. 19, no. 3, pp. 176-181. https://doi.org/10.4103/aam.aam_20_19

TY - JOUR

T1 - Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria

AU - Magaji, Francis Ajang

AU - Okolo, Mark Ojogba

AU - Hassan, Z.

AU - Shambe, Iornum H.

AU - Pam, Victor Chung

AU - Ocheke, Amaka Ngozi

AU - Yiltok, Esther S.

AU - Golit, Williams

AU - Anzaku, Stephen Ajen

AU - Daloek, Martins

AU - Ogwuche, Jerry

AU - Imade, Godwin E.

AU - Isichie, Christain

AU - Mutihir, Jsiah T.

AU - Oguche, Stephen

AU - Agbaji, Oche

AU - Musa, Jonah

AU - Sagay, Solomon Ateine

AU - Zoakah, A. I.

AU - Cohn, Susan E.

N1 - Funding Information: The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Office of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: The research reported in this publication was supported by the Fogarty International Centre of the National Institutes of Health and also the Offce of the Director, National Institutes of Health (OD), National Institute of Nursing Research, and the National Institutes of Neurological Disorders and Stroke under award number D43TW010130. The content is solely the responsibility of the authors and does not necessarily represent the offcial views of the National Institutes of Health. Publisher Copyright: © 2020 Annals of African Medicine Published by Wolters Kluwer-Medknow.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Objectives: The study sought to determine the prevalence and risk factors associated with Hepatitis B surface antigenemia (HBsAg) positivity among pregnant women in Jos, Nigeria. Methodology: This was a cross-sectional study carried out among the pregnant population in five healthcare facilities in Jos, between November 1, 2017 and April 30, 2018. Informed consent was obtained, and data on sociodemographic and risk factors for hepatitis B virus (HBV) infection were collected. Hepatitis B viral infection was assessed using the in vitro HBsAg diagnostic rapid kit (Acon Laboratories, USA). Descriptive statistics, Chi-square test, and logistic regression were performed to identify predictors of HBV infection in the study population. All statistical analyses were carried out on STATA version 15. Results: Of the 3,238 women enrolled, 7.4% (241/3238) (95% confidence interval [CI] = 6.6% to 8.4%) were HBsAg positive. The absence of HBV vaccination (adjusted odds ratio [AOR] = 2.49; 95% CI = 1.49-4.09; P < 0.001), co-infection with HIV (AOR = 1.90; 95% CI = 1.18-3.08; P = 0.009), and higher parity (AOR = 1.37; 95% CI = 1.04-1.79; P = 0.024) were independently associated with HBV infection in pregnancy. Conclusions: The prevalence of HBV infection among pregnant women was high, especially among those without prior vaccination for HBV, those with HIV co-infection and higher parity.

AB - Objectives: The study sought to determine the prevalence and risk factors associated with Hepatitis B surface antigenemia (HBsAg) positivity among pregnant women in Jos, Nigeria. Methodology: This was a cross-sectional study carried out among the pregnant population in five healthcare facilities in Jos, between November 1, 2017 and April 30, 2018. Informed consent was obtained, and data on sociodemographic and risk factors for hepatitis B virus (HBV) infection were collected. Hepatitis B viral infection was assessed using the in vitro HBsAg diagnostic rapid kit (Acon Laboratories, USA). Descriptive statistics, Chi-square test, and logistic regression were performed to identify predictors of HBV infection in the study population. All statistical analyses were carried out on STATA version 15. Results: Of the 3,238 women enrolled, 7.4% (241/3238) (95% confidence interval [CI] = 6.6% to 8.4%) were HBsAg positive. The absence of HBV vaccination (adjusted odds ratio [AOR] = 2.49; 95% CI = 1.49-4.09; P < 0.001), co-infection with HIV (AOR = 1.90; 95% CI = 1.18-3.08; P = 0.009), and higher parity (AOR = 1.37; 95% CI = 1.04-1.79; P = 0.024) were independently associated with HBV infection in pregnancy. Conclusions: The prevalence of HBV infection among pregnant women was high, especially among those without prior vaccination for HBV, those with HIV co-infection and higher parity.

KW - Hepatitis-B virus infection

KW - Nigeria

KW - pregnancy

KW - prevalence

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UR - http://www.scopus.com/inward/citedby.url?scp=85089768929&partnerID=8YFLogxK

U2 - 10.4103/aam.aam_20_19

DO - 10.4103/aam.aam_20_19

M3 - Article

C2 - 32820729

AN - SCOPUS:85089768929

SN - 1596-3519

VL - 19

SP - 176

EP - 181

JO - Annals of African Medicine

JF - Annals of African Medicine

IS - 3

ER -

Prevalence of hepatitis B virus infection among pregnant women in Jos, Nigeria

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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