Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study

Ban Traore; Yaya Kassogue; Brehima Diakite; Fousseyni Diarra; Kadidiatou Cisse; Oumar Kassogue; Modibo Diarra; Aissata Coulibaly; Bourama Coulibaly; Hama Diallo; Zoumana Diarra; Madani Ly; Aminata Maiga; Sidi Boula Sissoko; Adama Seydou Sissoko; Cheick Bougadari Traore; Bakarou Kamate; Ibrahima Teguete; Sekou Bah; Guimogo Dolo; Demirkan Besim Gursel; Jane Holl; Lifang Hou; Mamoudou Maiga

doi:10.1186/s12879-024-09412-y

Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study

Ban Traore, Yaya Kassogue^*, Brehima Diakite, Fousseyni Diarra, Kadidiatou Cisse, Oumar Kassogue, Modibo Diarra, Aissata Coulibaly, Bourama Coulibaly, Hama Diallo, Zoumana Diarra, Madani Ly, Aminata Maiga, Sidi Boula Sissoko, Adama Seydou Sissoko, Cheick Bougadari Traore, Bakarou Kamate, Ibrahima Teguete, Sekou Bah, Guimogo DoloDemirkan Besim Gursel, Jane Holl, Lifang Hou, Mamoudou Maiga

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods: This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results: The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion: Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.

Original language	English (US)
Article number	513
Journal	BMC Infectious Diseases
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s12879-024-09412-y
State	Published - Dec 2024

Funding

This study was supported by the NCI training grant D43CA260658 (Infection Associated Cancers in Mali) and U01CA275129 (West Africa Self-Sampling HPV Based Cervical Cancer Control Program: Barriers, challenges, and needs). The authors thank the Centre of Research and Training on Molecular Pathologies (CREFPAM), University Hospital of Point G, the Faculty of Medicine and Odontostomatology/University of Sciences, Techniques, and Technologies of Bamako, the University Clinical Research Center (UCRC-Mali), International Center of Excellence in Research Mali (ICER-Mali), all participants in the study.

Keywords

Genotypes
Hr-HPV
Mali
Self-sampling
WLWHIV

ASJC Scopus subject areas

Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12879-024-09412-y

Cite this

Traore, B., Kassogue, Y., Diakite, B., Diarra, F., Cisse, K., Kassogue, O., Diarra, M., Coulibaly, A., Coulibaly, B., Diallo, H., Diarra, Z., Ly, M., Maiga, A., Sissoko, S. B., Sissoko, A. S., Traore, C. B., Kamate, B., Teguete, I., Bah, S., ... Maiga, M. (2024). Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study. BMC Infectious Diseases, 24(1), Article 513. https://doi.org/10.1186/s12879-024-09412-y

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title = "Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study",

abstract = "Introduction: Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women{\textquoteright}s adherence and increase screening rates. Methods: This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results: The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion: Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.",

keywords = "Genotypes, Hr-HPV, Mali, Self-sampling, WLWHIV",

author = "Ban Traore and Yaya Kassogue and Brehima Diakite and Fousseyni Diarra and Kadidiatou Cisse and Oumar Kassogue and Modibo Diarra and Aissata Coulibaly and Bourama Coulibaly and Hama Diallo and Zoumana Diarra and Madani Ly and Aminata Maiga and Sissoko, {Sidi Boula} and Sissoko, {Adama Seydou} and Traore, {Cheick Bougadari} and Bakarou Kamate and Ibrahima Teguete and Sekou Bah and Guimogo Dolo and Gursel, {Demirkan Besim} and Jane Holl and Lifang Hou and Mamoudou Maiga",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1186/s12879-024-09412-y",

language = "English (US)",

volume = "24",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

number = "1",

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Traore, B, Kassogue, Y, Diakite, B, Diarra, F, Cisse, K, Kassogue, O, Diarra, M, Coulibaly, A, Coulibaly, B, Diallo, H, Diarra, Z, Ly, M, Maiga, A, Sissoko, SB, Sissoko, AS, Traore, CB, Kamate, B, Teguete, I, Bah, S, Dolo, G, Gursel, DB, Holl, J, Hou, L & Maiga, M 2024, 'Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study', BMC Infectious Diseases, vol. 24, no. 1, 513. https://doi.org/10.1186/s12879-024-09412-y

TY - JOUR

T1 - Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV

T2 - a pilot study

AU - Traore, Ban

AU - Kassogue, Yaya

AU - Diakite, Brehima

AU - Diarra, Fousseyni

AU - Cisse, Kadidiatou

AU - Kassogue, Oumar

AU - Diarra, Modibo

AU - Coulibaly, Aissata

AU - Coulibaly, Bourama

AU - Diallo, Hama

AU - Diarra, Zoumana

AU - Ly, Madani

AU - Maiga, Aminata

AU - Sissoko, Sidi Boula

AU - Sissoko, Adama Seydou

AU - Traore, Cheick Bougadari

AU - Kamate, Bakarou

AU - Teguete, Ibrahima

AU - Bah, Sekou

AU - Dolo, Guimogo

AU - Gursel, Demirkan Besim

AU - Holl, Jane

AU - Hou, Lifang

AU - Maiga, Mamoudou

PY - 2024/12

Y1 - 2024/12

N2 - Introduction: Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods: This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results: The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion: Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.

AB - Introduction: Long-term exposure to high-risk human papillomavirus (Hr-HPV) is a well-known necessary condition for development of cervical cancer. The aim of this study is to screen for Hr-HPV using vaginal self-sampling, which is a more effective approach to improve women’s adherence and increase screening rates. Methods: This pilot study included a total of 100 Women living with HIV (WLWHIV), recruited from the Center for Listening, Care, Animation, and Counseling of People Living with HIV in Bamako. Hr-HPV genotyping was performed on Self-collected samples using the Cepheid GeneXpert instrument. Results: The median age of WLWHIV was 44 (interquartile range [IQR], 37–50) years. Approximately 92% of the study participants preferred self-sampling at the clinic, and 90% opted to receive result notifications via mobile phone contact. The overall prevalence of Hr-HPV among study participants was 42.6%, and the most frequent Hr-HPV sub-types observed were HPV18/45 (19.1%), HPV31/35/33/52/58 (13.8%), and HPV39/68/56/66 (12.8%), followed by HPV16 (5.3%), and HPV51/59 (5.3%). WLWHIV under 35 years of age had a higher frequency of Hr-HPV compared to their older counterparts, with rates of 30% versus 11.1% (p = 0.03). The duration of antiretroviral treatment showed an inverse association with Hr-HPV negativity, with patients on treatment for 15 (IQR, 10–18) years versus 12 (IQR = 7–14) years for Hr-HPV positive patients (95% CI [1.2–5.8], t = 3.04, p = 0.003). WLWHIV with baseline CD4 T-Cell counts below 200 exhibited a higher frequency of Hr-HPV compared to those with baseline CD4 T-Cell counts above 200 (17.9% versus 1.9%, p = 0.009). However, other demographics and clinical factors, such as marital status, age of sexual debut, parity, education, history of abortion, history of preeclampsia, and cesarean delivery, did not influence the distribution of Hr-HPV genotypes. Conclusion: Our findings indicate that WLWHIV under the age of 35 years old exhibited the highest prevalence of Hr-HPV infection, with HPV18/45 being the most prevalent subtype. Additionally, WLWHIV with baseline CD4 T-Cell counts below 200 showed the highest infection rates.

KW - Genotypes

KW - Hr-HPV

KW - Mali

KW - Self-sampling

KW - WLWHIV

UR - http://www.scopus.com/inward/record.url?scp=85194021178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85194021178&partnerID=8YFLogxK

U2 - 10.1186/s12879-024-09412-y

DO - 10.1186/s12879-024-09412-y

M3 - Article

C2 - 38778266

AN - SCOPUS:85194021178

SN - 1471-2334

VL - 24

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

M1 - 513

ER -

Prevalence of high-risk human papillomavirus genotypes in outpatient Malian women living with HIV: a pilot study

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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