Prevalence of periodontal diseases in a multicenter cohort of perinatally HIV-infected and HIV-exposed and uninfected youth

Mark I. Ryder*, Tzy Jyun Yao, Jonathan S. Russell, Anna Barbara Moscicki, Caroline H. Shiboski, Ester Yang, William Shearer, Mary Paul, Norma Cooper, Lynette Harris, Karen Kemp-Posterman, Selene Wun, Murli Purswani, Mahboobullah Baig, Anna Cintron, Jennifer Zeni, Ana Puga, Sandra Navarro, Doyle Patton, Deyana LeonMan Wai Ng, Sandra Burchett, Nancy Karthas, Betsy Kammerer, Ray Jurado, Johnny Kuttab, Ashlee Vorachek, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter, Victor Badner, Ronald Garreett, Andrew Wiznia, Marlene Burey, Molly Nozyce, Susan Chialastri, Janet Chen, Latreca Ivey, Maria Garcia Bulkley, Mitzie Grant, Ramon Gonzalez, Midnela Acevedo-Flores, Heida Rios, Vivian Olivera, Janice Townsend, Margarita Silio, Medea Jones, Patricia Sirois, Roopa Gandhi, the Pediatric HIV/AIDS Cohort Study

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Aims: To compare the prevalence and severity of periodontal diseases between 180 perinatally HIV-infected (PHIV) and 118 perinatally HIV-exposed and uninfected (PHEU) youth in a cross-sectional study conducted at 11 clinical sites in the United States and Puerto Rico from the Adolescent Master Protocol study of the Pediatric HIV/AIDS cohort study (PHACS) network. Methods: Several analyses were conducted, employing the current CDC/AAP classification for periodontitis and incorporating a definition of gingivitis based on a bleeding on probing (BOP) threshold, and analyses based on more detailed whole-mouth, intra-oral regionally, site-based and tooth-based criteria of BOP, plaque levels, pockets depths and clinical attachment levels. Results: After adjusting for plaque control habits and behavioural and sociodemographic factors, there were no significant differences in periodontal diseases between the PHIV and PHEU youth using any of these criteria. For PHIV youth, there was no significant association between parameters of periodontal disease and current HIV status. Conclusions: Although no significant differences in periodontal parameters were noted between the PHIV and PHEU youth, the influence of antiretroviral therapy merits further exploration in this cohort in a longitudinal study.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalJournal of Clinical Periodontology
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2017

Funding

The following institutions, clinical site investigators and staff participated in conducting the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol in 2012, in alphabetical order: Baylor College of Medicine: Ester Yang*, William Shearer, Mary Paul, Norma Cooper, Lynette Harris; Bronx Lebanon Hospital Center: Karen Kemp-Posterman*, Selene Wun*, Murli Purswani, Mahboobullah Baig, Anna Cintron; Children's Diagnostic and Treatment Center: Jennifer Zeni*, Ana Puga, Sandra Navarro, Doyle Patton, Deyana Leon; Children's Hospital, Boston: Man Wai Ng*, Sandra Burchett, Nancy Karthas, Betsy Kammerer; Ann and Robert H. Lurie Children's Hospital of Chicago: Ray Jurado*, Johnny Kuttab*, Ashlee Vorachek*, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter; Jacobi Medical Center: Victor Badner*, Ronald Garreett*, Andrew Wiznia, Marlene Burey, Molly Nozyce; St. Christopher's Hospital for Children: Susan Chialastri*, Janet Chen, Latreca Ivey, Maria Garcia Bulkley, Mitzie Grant; San Juan Hospital/Department of Pediatrics: Ramon Gonzalez*, Midnela Acevedo-Flores, Heida Rios, Vivian Olivera; Tulane University Health Sciences Center: Janice Townsend*, Margarita Silio, Medea Jones, Patricia Sirois; University of Colorado Denver Health Sciences Center: Roopa Gandhi*, Elizabeth McFarland, Emily Barr, Robin McEvoy; University of Medicine and Dentistry of New Jersey: Kenneth Markowitz*, Arry Dieudonne, Linda Bettica, Susan Adubato; the authors thank the children and families for their participation in PHACS, and the individuals and institutions involved in the conduct of PHACS. *Participating Dentist.

Keywords

  • HIV
  • gingivitis
  • periodontal disease
  • youth

ASJC Scopus subject areas

  • Periodontics

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