TY - JOUR
T1 - Prevalence of sleep disturbances in children and adolescents with chronic kidney disease
AU - Davis, Ira D.
AU - Greenbaum, Larry A.
AU - Gipson, Debbie
AU - Wu, Lie Ling
AU - Sinha, Rajiv
AU - Matsuda-Abedini, Mina
AU - Emancipator, Judith L.
AU - Lane, Jerome C.
AU - Hodgkins, Kavita
AU - Nailescu, Corina
AU - Barletta, Gina Marie
AU - Arora, Steven
AU - Mahan, John D.
AU - Rosen, Carol L.
N1 - Funding Information:
This study was funded by the Leonard C. Rosenberg Foundation, a support organization of the Centers for Dialysis Care, Cleveland, Ohio.
PY - 2012/3
Y1 - 2012/3
N2 - Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to healthrelated quality of life measurements. We performed a clinicbased survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep. Patients and the parent-proxy also completed the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales questionnaire. Ninety-three (93) patients (58.5%) had symptoms of a sleep disturbance. The presence of a sleep disturbance correlated with a decrease in health-related quality of life scores that was independent of the chronic kidney disease study group or estimated glomerular filtration rate. We conclude that sleep disturbances are common throughout the spectrum of chronic kidney disease in children and adolescents and are associated with diminished healthrelated quality of life scores.
AB - Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to healthrelated quality of life measurements. We performed a clinicbased survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep. Patients and the parent-proxy also completed the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales questionnaire. Ninety-three (93) patients (58.5%) had symptoms of a sleep disturbance. The presence of a sleep disturbance correlated with a decrease in health-related quality of life scores that was independent of the chronic kidney disease study group or estimated glomerular filtration rate. We conclude that sleep disturbances are common throughout the spectrum of chronic kidney disease in children and adolescents and are associated with diminished healthrelated quality of life scores.
KW - Dialysis
KW - Excessive daytime sleepiness
KW - Health-related quality of life
KW - Renal transplantation
KW - Restless legs syndrome
KW - Sleep disordered breathing
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U2 - 10.1007/s00467-011-2010-y
DO - 10.1007/s00467-011-2010-y
M3 - Article
C2 - 21964556
AN - SCOPUS:84857056889
SN - 0931-041X
VL - 27
SP - 451
EP - 459
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 3
ER -