Prevalence of sleep disturbances in children and adolescents with chronic kidney disease

Ira D. Davis*, Larry A. Greenbaum, Debbie Gipson, Lie Ling Wu, Rajiv Sinha, Mina Matsuda-Abedini, Judith L. Emancipator, Jerome C. Lane, Kavita Hodgkins, Corina Nailescu, Gina Marie Barletta, Steven Arora, John D. Mahan, Carol L. Rosen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to healthrelated quality of life measurements. We performed a clinicbased survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep. Patients and the parent-proxy also completed the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales questionnaire. Ninety-three (93) patients (58.5%) had symptoms of a sleep disturbance. The presence of a sleep disturbance correlated with a decrease in health-related quality of life scores that was independent of the chronic kidney disease study group or estimated glomerular filtration rate. We conclude that sleep disturbances are common throughout the spectrum of chronic kidney disease in children and adolescents and are associated with diminished healthrelated quality of life scores.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalPediatric Nephrology
Issue number3
StatePublished - Mar 2012


  • Dialysis
  • Excessive daytime sleepiness
  • Health-related quality of life
  • Renal transplantation
  • Restless legs syndrome
  • Sleep disordered breathing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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