Preventable adverse drug events in hospitalized patients: A comparative study of intensive care and general care units

David J. Cullen*, Bobbie Jean Sweitzer, David W. Bates, Elisabeth Burdick, Amy Edmondson, Lucian L. Leape

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

472 Scopus citations

Abstract

Objectives: To compare the frequency and preventability of adverse drug events and potential adverse drug events. In intensive care units (ICUs) and non-ICUs. To evaluate systems factors involving the individual caregivers, care unit teams, and patients involved in each adverse drug event by comparing ICUs with nonICUs and medical ICUs with surgical ICUs. Design: Prospective cohort study. Participants included all 4.031 adult admissions to a stratified, random sample of 11 medical and surgical units in two tertiary care hospitals over a 6-month period. Units included two medical and three surgical ICUs and four medical and two surgical general care units. Setting: Two tertiary care hospitals: Eleven medical and surgical units, including two medical and three surgical ICUs. Patients: Adult admissions (n = 4,031). Interventions: None. Measurements end Main Results: Rate of preventable adverse drug events and potential adverse drug events, length of stay, charges, costs, and measures of the unit's environment. Incidents were detected by stimulated self-report by nurses and pharmacists and by daily review of all charts by nurse investigators. Incidents were subsequently classified by two independent reviewers as to whether they represented adverse drug events or potential adverse drug events ane as to severity and preventability. Those individuals involved in the preventable adverse drug event and potential adverse drug event underwent detailed interviews by peer case-investigators. The rate of preventable adverse drug events and potential adverse drug events in ICUs was 19 events per 1000 patient days, nearly twice that rate of non-ICUs (P < .01). The medical ICU rate (25 events per 1000 patient days) was significantly (P < .05) higher than the surgical ICU rate (14 events per 1000 patient days). When adjusted to) the number of drugs used in the previous 24 hrs or ordered since admission, there were no differences in rates between ICUs and non-ICUs. ICU acuity, length of stay, and severity of the adverse drug event were greater in ICUs than non-ICUs, but there were no differences between medical ICU and surgical ICU patients. Structured interviews indicated almost no differences between ICUs and non-ICUs for many characteristics of the patient, patient care team, systems, and individual caregivers. Conclusions: The rate of preventable and potential adverse drug events was twice as high in ICUs compared with non-ICUs. However, when adjusted for the number of drugs ordered, there was no greater likelihood for preventable adverse drug events and potential adverse drug events to occur h ICUs than in non-ICUs. Preventable adverse drug events and potential adverse drug events occurred in units that functioned normally and involved caregivers who were working under reasonably normal circumstances, not at the extremes of workload, stress, or a difficult environment.

Original languageEnglish (US)
Pages (from-to)1289-1297
Number of pages9
JournalCritical care medicine
Volume25
Issue number8
DOIs
StatePublished - Aug 1 1997

Keywords

  • Adverse drug events
  • Costs
  • General care unit
  • Intensive care unit
  • Length of stay
  • Medical unit
  • Severity of illness
  • Structured interviews
  • Surgical unit

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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