Prevention and reversal of renal allograft rejection by antibody against CD45RB

Andrew I. Lazarovits*, Sibrand Poppema, Zheng Zhang, Masud Khandaker, Catherine E. Le Feuvre, Sharwan K. Singhal, Bertha M. Garcia, Nobuaki Ogasa, Anthony M. Jevnikar, Martin J. White, Gargi Singh, Calvin R. Stiller, Robert Z. Zhong

*Corresponding author for this work

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

Rejection continues to be the single largest impediment to successful organ transplantation. Antilymphocyte globulin, which contains antibodies that react with the leukocyte common antigen known as CD45, has proved to be one of the most effective agents for preventing rejection. We have shown earlier that a monoclonal antibody directed against the RB isoform of CD45 substantially inhibits the alloreactivity of human CD4+ lymphocytes in vitro. Here we investigate whether CD45RB could be an appropriate target for preventing renal allograft rejection in mice. Mice treated with two injections of a monoclonal antibody (MB23G2) raised against CD45RB protein all survived and had normal renal function. Furthermore, this antibody reversed acute rejection when therapy was delayed until day 4, and the mice survived for their natural lifespan. The immunosuppression achieved may find application in the prevention and treatment of transplant rejection in man.

Original languageEnglish (US)
Pages (from-to)717-720
Number of pages4
JournalNature
Volume380
Issue number6576
DOIs
StatePublished - Apr 25 1996

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Prevention and reversal of renal allograft rejection by antibody against CD45RB'. Together they form a unique fingerprint.

  • Cite this

    Lazarovits, A. I., Poppema, S., Zhang, Z., Khandaker, M., Le Feuvre, C. E., Singhal, S. K., Garcia, B. M., Ogasa, N., Jevnikar, A. M., White, M. J., Singh, G., Stiller, C. R., & Zhong, R. Z. (1996). Prevention and reversal of renal allograft rejection by antibody against CD45RB. Nature, 380(6576), 717-720. https://doi.org/10.1038/380717a0