Prevention of allograft rejection by amplification of Foxp3+CD4+CD25+ regulatory T cells

Guliang Xia, Malathi Shah, Xunrong Luo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


CD4+CD25+ T cells were identified originally as potent suppressors of autoimmunity and were later termed "natural regulatory T cells" or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3+CD4+CD25+ Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3+CD4+CD25+ Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.

Original languageEnglish (US)
Pages (from-to)60-70
Number of pages11
JournalTranslational Research
Issue number2
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)


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