Prevention of chymopapain anaphylaxis by screening chemonucleolysis candidates with cutaneous chymopapain testing

L. C. Grammer, M. Schafer, D. Bernstein, I. L. Bernstein, F. Cogen, J. Dolovich, M. Schatz, R. Zeiger, J. J. Shaughnessy, L. Gutt, M. Roberts, R. Patterson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

With chymopapain at a concentration of 10 mg/ml, the authors skin tested 540 chemonucleolysis candidates; six were positive, and 534 were negative. None of the positive patients received therapeutic injections of chymopapain. There were no instances of unequivocal anaphylaxis to chymopapain in the patients with negative skin tests treated with chymopapain. When this 0% incidence of systemic reactions in skin test negative patients is compared with the historical rate of 1%, this difference is statistically significant (p < 0.05). Restriction of chymopapain treatment to patients with negative prick tests can reduce the incidence of systemic reactions.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalClinical orthopaedics and related research
Issue number234
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Prevention of chymopapain anaphylaxis by screening chemonucleolysis candidates with cutaneous chymopapain testing'. Together they form a unique fingerprint.

  • Cite this

    Grammer, L. C., Schafer, M., Bernstein, D., Bernstein, I. L., Cogen, F., Dolovich, J., Schatz, M., Zeiger, R., Shaughnessy, J. J., Gutt, L., Roberts, M., & Patterson, R. (1988). Prevention of chymopapain anaphylaxis by screening chemonucleolysis candidates with cutaneous chymopapain testing. Clinical orthopaedics and related research, (234), 12-15. https://doi.org/10.1097/00003086-198809000-00003