Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts

Shu Qian Liu; M. M. Moore

Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts

Shu Qian Liu^*, M. M. Moore

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Vein grafts, a unique type of blood vessels, are subject to increased tensile stress due to exposure to arterial blood pressure, and have been used to study the mechanism of mechanical regulation of vascular remodelling. Two experimental models were created in rats, a nonengineered vein graft with increased tensile stress and a nonengineered vein graft with reduced tensile stress, to study the influence of mechanical stretch to cell death in vein grafts. In addition to surgical trauma, it is found that mechanical stretch due to exposure to arterial blood pressure contributes significantly to endothelial cell and smooth muscle cell injury and death.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publisher	IEEE
Number of pages	1
Volume	1
ISBN (Print)	0780356756
State	Published - Dec 1 1999
Event	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA Duration: Oct 13 1999 → Oct 16 1999

Other

Other	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
City	Atlanta, GA, USA
Period	10/13/99 → 10/16/99

ASJC Scopus subject areas

Bioengineering

Cite this

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title = "Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts",

abstract = "Vein grafts, a unique type of blood vessels, are subject to increased tensile stress due to exposure to arterial blood pressure, and have been used to study the mechanism of mechanical regulation of vascular remodelling. Two experimental models were created in rats, a nonengineered vein graft with increased tensile stress and a nonengineered vein graft with reduced tensile stress, to study the influence of mechanical stretch to cell death in vein grafts. In addition to surgical trauma, it is found that mechanical stretch due to exposure to arterial blood pressure contributes significantly to endothelial cell and smooth muscle cell injury and death.",

author = "Liu, {Shu Qian} and Moore, {M. M.}",

year = "1999",

month = dec,

day = "1",

language = "English (US)",

isbn = "0780356756",

volume = "1",

booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

publisher = "IEEE",

note = "Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) ; Conference date: 13-10-1999 Through 16-10-1999",

}

Liu, SQ & Moore, MM 1999, Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

TY - GEN

T1 - Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts

AU - Liu, Shu Qian

AU - Moore, M. M.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Vein grafts, a unique type of blood vessels, are subject to increased tensile stress due to exposure to arterial blood pressure, and have been used to study the mechanism of mechanical regulation of vascular remodelling. Two experimental models were created in rats, a nonengineered vein graft with increased tensile stress and a nonengineered vein graft with reduced tensile stress, to study the influence of mechanical stretch to cell death in vein grafts. In addition to surgical trauma, it is found that mechanical stretch due to exposure to arterial blood pressure contributes significantly to endothelial cell and smooth muscle cell injury and death.

AB - Vein grafts, a unique type of blood vessels, are subject to increased tensile stress due to exposure to arterial blood pressure, and have been used to study the mechanism of mechanical regulation of vascular remodelling. Two experimental models were created in rats, a nonengineered vein graft with increased tensile stress and a nonengineered vein graft with reduced tensile stress, to study the influence of mechanical stretch to cell death in vein grafts. In addition to surgical trauma, it is found that mechanical stretch due to exposure to arterial blood pressure contributes significantly to endothelial cell and smooth muscle cell injury and death.

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M3 - Conference contribution

AN - SCOPUS:0033348558

SN - 0780356756

VL - 1

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

PB - IEEE

T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)

Y2 - 13 October 1999 through 16 October 1999

ER -

Prevention of mechanical stretch-induced endothelial and smooth muscle cell death in experimental vein grafts

Abstract

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ASJC Scopus subject areas

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