Prevention of mutagenesis: New potential mechanisms of metformin action in neoplastic cells

Fréd́eric Bost*, Issam Ben-Sahra, Jean Franco̧is Tanti

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalCancer Prevention Research
Volume5
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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