TY - JOUR
T1 - Prevention of mutagenesis
T2 - New potential mechanisms of metformin action in neoplastic cells
AU - Bost, Fréd́eric
AU - Ben-Sahra, Issam
AU - Tanti, Jean Franco̧is
PY - 2012/4
Y1 - 2012/4
N2 - Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug.
AB - Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug.
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U2 - 10.1158/1940-6207.CAPR-12-0085
DO - 10.1158/1940-6207.CAPR-12-0085
M3 - Review article
C2 - 22491515
AN - SCOPUS:84864851436
SN - 1940-6207
VL - 5
SP - 503
EP - 506
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 4
ER -
