Prevention of Perinatal Transmission of Human Immunodeficiency Virus

Catherine A. Chappell; Susan E. Cohn

doi:10.1016/j.idc.2014.08.002

Prevention of Perinatal Transmission of Human Immunodeficiency Virus

Catherine A. Chappell, Susan E. Cohn^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The reproductive health needs of all women of childbearing age should routinely address effective and appropriate contraception, safer sex practices, and elimination of alcohol, illicit drugs and tobacco should pregnancy occur. Combined antepartum, intrapartum, and infant antiretroviral (ARV) prophylaxis are recommended because ARV drugs reduce perinatal transmission by several mechanisms, including lowering maternal viral load and providing infant pre- and post-exposure prophylaxis. Scheduled cesarean delivery at 38 weeks with IV AZT decreases the risk of perinatal transmission if the HIV RNA is greater than 1000 copies/mL or if HIV levels are unknown near the time of delivery. Oral AZT should generally be given for at least 6 weeks to all infants perinatally exposed to HIV to reduce perinatal transmission of HIV.

Original language	English (US)
Pages (from-to)	529-547
Number of pages	19
Journal	Infectious disease clinics of North America
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.idc.2014.08.002
State	Published - Dec 1 2014

Keywords

Antiretroviral medication
Contraception
Human immunodeficiency virus
Perinatal transmission
Pregnancy

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.idc.2014.08.002

Cite this

@article{4a35865b31f4499ca393859d48a09413,

title = "Prevention of Perinatal Transmission of Human Immunodeficiency Virus",

abstract = "The reproductive health needs of all women of childbearing age should routinely address effective and appropriate contraception, safer sex practices, and elimination of alcohol, illicit drugs and tobacco should pregnancy occur. Combined antepartum, intrapartum, and infant antiretroviral (ARV) prophylaxis are recommended because ARV drugs reduce perinatal transmission by several mechanisms, including lowering maternal viral load and providing infant pre- and post-exposure prophylaxis. Scheduled cesarean delivery at 38 weeks with IV AZT decreases the risk of perinatal transmission if the HIV RNA is greater than 1000 copies/mL or if HIV levels are unknown near the time of delivery. Oral AZT should generally be given for at least 6 weeks to all infants perinatally exposed to HIV to reduce perinatal transmission of HIV.",

keywords = "Antiretroviral medication, Contraception, Human immunodeficiency virus, Perinatal transmission, Pregnancy",

author = "Chappell, {Catherine A.} and Cohn, {Susan E.}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.idc.2014.08.002",

language = "English (US)",

volume = "28",

pages = "529--547",

journal = "Infectious disease clinics of North America",

issn = "0891-5520",

publisher = "W.B. Saunders",

number = "4",

}

TY - JOUR

T1 - Prevention of Perinatal Transmission of Human Immunodeficiency Virus

AU - Chappell, Catherine A.

AU - Cohn, Susan E.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The reproductive health needs of all women of childbearing age should routinely address effective and appropriate contraception, safer sex practices, and elimination of alcohol, illicit drugs and tobacco should pregnancy occur. Combined antepartum, intrapartum, and infant antiretroviral (ARV) prophylaxis are recommended because ARV drugs reduce perinatal transmission by several mechanisms, including lowering maternal viral load and providing infant pre- and post-exposure prophylaxis. Scheduled cesarean delivery at 38 weeks with IV AZT decreases the risk of perinatal transmission if the HIV RNA is greater than 1000 copies/mL or if HIV levels are unknown near the time of delivery. Oral AZT should generally be given for at least 6 weeks to all infants perinatally exposed to HIV to reduce perinatal transmission of HIV.

AB - The reproductive health needs of all women of childbearing age should routinely address effective and appropriate contraception, safer sex practices, and elimination of alcohol, illicit drugs and tobacco should pregnancy occur. Combined antepartum, intrapartum, and infant antiretroviral (ARV) prophylaxis are recommended because ARV drugs reduce perinatal transmission by several mechanisms, including lowering maternal viral load and providing infant pre- and post-exposure prophylaxis. Scheduled cesarean delivery at 38 weeks with IV AZT decreases the risk of perinatal transmission if the HIV RNA is greater than 1000 copies/mL or if HIV levels are unknown near the time of delivery. Oral AZT should generally be given for at least 6 weeks to all infants perinatally exposed to HIV to reduce perinatal transmission of HIV.

KW - Antiretroviral medication

KW - Contraception

KW - Human immunodeficiency virus

KW - Perinatal transmission

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=84912562540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84912562540&partnerID=8YFLogxK

U2 - 10.1016/j.idc.2014.08.002

DO - 10.1016/j.idc.2014.08.002

M3 - Review article

C2 - 25455313

AN - SCOPUS:84912562540

SN - 0891-5520

VL - 28

SP - 529

EP - 547

JO - Infectious disease clinics of North America

JF - Infectious disease clinics of North America

IS - 4

ER -

Prevention of Perinatal Transmission of Human Immunodeficiency Virus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this