Preventive potential of body mass reduction to lower cardiovascular risk: The Italian Progetto CUORE study

Salvatore Panico*, Luigi Palmieri, Chiara Donfrancesco, Diego Vanuzzo, Paolo Chiodini, Giancarlo Cesana, Marco Ferrario, Amalia Mattiello, Lorenza Pilotto, Roberto Sega, Simona Giampaoli, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: To estimate effects of weight change on incidence of major cardiovascular events in the Italian population-based Progetto CUORE. Methods: Prospective observation in 12 Italian population-based cohorts on etiology of cardiovascular disease. Twenty-thousand six-hundred-forty-seven men and women aged 35-69 years without previous CVD, examined at baseline between 1984 and 1993 and followed for median time 8.5 years, with validated first cardiovascular events. Standardised anthropometric variables, lifestyle and biochemical risk factors for CVD; major cardiovascular events as end-points. Results: Linear regression between BMI and major CVD risk factors was combined with Cox coefficients from a prediction model of CVD, CHD and stroke using major risk factors as dependent variables. Estimated cardiovascular risk reductions with BMI lowered by 1 to 3 U were: for men 3.8% to 10.9% for all cardiovascular events, 4.2% to 12.1% for CHD, and 2.3% to 6.9% for stroke; for women 2.8% to 8.1% for all cardiovascular events, 3.4% to 9.8% for CHD, and 2.1% to 6.2% for stroke. Conclusions: Body weight level influences cardiovascular disease risk in the Italian population.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalPreventive medicine
Issue number1
StatePublished - Jul 2008


  • Body mass index
  • Cardiovascular disease
  • Coronary heart disease
  • Population data
  • Prevention
  • Weight reduction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology


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