Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease

A. Kyle Mack*, Alexis A. Thompson

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Children with sickle cell disease (SCD) have numerous acute and chronic complications, including central nervous system (CNS) disease, which can be debilitating over their life span. Recognition of risk factors for CNS disease and overt CNS disease should be properly identified by primary care providers, including physicians, physician assistants, and nurse practitioners. Here, we discuss an emerging and important early indicator of CNS disease in the form of silent cerebral infarcts and review overt stroke in patients with SCD. We also discuss transcranial Doppler ultrasonography, when and how often transcranial Doppler ultrasounds should be performed, and management of abnormal results. Lastly, we review the clinical data for the management and prevention of silent cerebral infarcts and overt stroke in children with SCD.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalJournal of Pediatric Health Care
Volume31
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Central Nervous System Diseases
Sickle Cell Anemia
Secondary Prevention
Stroke
Doppler Transcranial Ultrasonography
Physician Assistants
Doppler Ultrasonography
Nurse Practitioners
Primary Health Care
Physicians

Keywords

  • Cerebral infarct
  • sickle cell disease
  • stroke
  • transcranial Doppler ultrasonography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{d7571bd1ac474c2b97294f07a3f8c53f,
title = "Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease",
abstract = "Children with sickle cell disease (SCD) have numerous acute and chronic complications, including central nervous system (CNS) disease, which can be debilitating over their life span. Recognition of risk factors for CNS disease and overt CNS disease should be properly identified by primary care providers, including physicians, physician assistants, and nurse practitioners. Here, we discuss an emerging and important early indicator of CNS disease in the form of silent cerebral infarcts and review overt stroke in patients with SCD. We also discuss transcranial Doppler ultrasonography, when and how often transcranial Doppler ultrasounds should be performed, and management of abnormal results. Lastly, we review the clinical data for the management and prevention of silent cerebral infarcts and overt stroke in children with SCD.",
keywords = "Cerebral infarct, sickle cell disease, stroke, transcranial Doppler ultrasonography",
author = "Mack, {A. Kyle} and Thompson, {Alexis A.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.pedhc.2016.06.005",
language = "English (US)",
volume = "31",
pages = "145--154",
journal = "Journal of Pediatric Health Care",
issn = "0891-5245",
publisher = "Mosby Inc.",
number = "2",

}

Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease. / Mack, A. Kyle; Thompson, Alexis A.

In: Journal of Pediatric Health Care, Vol. 31, No. 2, 01.03.2017, p. 145-154.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease

AU - Mack, A. Kyle

AU - Thompson, Alexis A.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Children with sickle cell disease (SCD) have numerous acute and chronic complications, including central nervous system (CNS) disease, which can be debilitating over their life span. Recognition of risk factors for CNS disease and overt CNS disease should be properly identified by primary care providers, including physicians, physician assistants, and nurse practitioners. Here, we discuss an emerging and important early indicator of CNS disease in the form of silent cerebral infarcts and review overt stroke in patients with SCD. We also discuss transcranial Doppler ultrasonography, when and how often transcranial Doppler ultrasounds should be performed, and management of abnormal results. Lastly, we review the clinical data for the management and prevention of silent cerebral infarcts and overt stroke in children with SCD.

AB - Children with sickle cell disease (SCD) have numerous acute and chronic complications, including central nervous system (CNS) disease, which can be debilitating over their life span. Recognition of risk factors for CNS disease and overt CNS disease should be properly identified by primary care providers, including physicians, physician assistants, and nurse practitioners. Here, we discuss an emerging and important early indicator of CNS disease in the form of silent cerebral infarcts and review overt stroke in patients with SCD. We also discuss transcranial Doppler ultrasonography, when and how often transcranial Doppler ultrasounds should be performed, and management of abnormal results. Lastly, we review the clinical data for the management and prevention of silent cerebral infarcts and overt stroke in children with SCD.

KW - Cerebral infarct

KW - sickle cell disease

KW - stroke

KW - transcranial Doppler ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84979500120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979500120&partnerID=8YFLogxK

U2 - 10.1016/j.pedhc.2016.06.005

DO - 10.1016/j.pedhc.2016.06.005

M3 - Article

VL - 31

SP - 145

EP - 154

JO - Journal of Pediatric Health Care

JF - Journal of Pediatric Health Care

SN - 0891-5245

IS - 2

ER -