Primary and Secondary Stroke Prevention in Children With Sickle Cell Disease

A. Kyle Mack*, Alexis A. Thompson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Children with sickle cell disease (SCD) have numerous acute and chronic complications, including central nervous system (CNS) disease, which can be debilitating over their life span. Recognition of risk factors for CNS disease and overt CNS disease should be properly identified by primary care providers, including physicians, physician assistants, and nurse practitioners. Here, we discuss an emerging and important early indicator of CNS disease in the form of silent cerebral infarcts and review overt stroke in patients with SCD. We also discuss transcranial Doppler ultrasonography, when and how often transcranial Doppler ultrasounds should be performed, and management of abnormal results. Lastly, we review the clinical data for the management and prevention of silent cerebral infarcts and overt stroke in children with SCD.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalJournal of Pediatric Health Care
Issue number2
StatePublished - Mar 1 2017


  • Cerebral infarct
  • sickle cell disease
  • stroke
  • transcranial Doppler ultrasonography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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