TY - JOUR
T1 - Primary central nervous system malignant melanoma in children
T2 - A case series and review of the literature
AU - Choi, Daniel K.
AU - Pillay Smiley, Natasha
AU - Marzec, Sarah
AU - Wadhwani, Nitin Ramesh
AU - DiPatri, Arthur J
AU - Tomita, Tadanori
AU - Lulla, Rishi R.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.
AB - We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.
KW - Central nervous system malignant melanoma
KW - Melanoma
KW - Pediatric brain tumor
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U2 - 10.1097/MPH.0000000000001092
DO - 10.1097/MPH.0000000000001092
M3 - Review article
C2 - 29401100
AN - SCOPUS:85055187402
VL - 40
SP - 616
EP - 619
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 8
ER -