Primary central nervous system malignant melanoma in children: A case series and review of the literature

Daniel K. Choi*, Natasha Pillay Smiley, Sarah Marzec, Nitin Ramesh Wadhwani, Arthur J DiPatri, Tadanori Tomita, Rishi R. Lulla

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.

Original languageEnglish (US)
Pages (from-to)616-619
Number of pages4
JournalJournal of pediatric hematology/oncology
Volume40
Issue number8
DOIs
StatePublished - Nov 1 2018

Keywords

  • Central nervous system malignant melanoma
  • Melanoma
  • Pediatric brain tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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