Primary central nervous system malignant melanoma in children: A case series and review of the literature

Daniel K. Choi; Natasha Pillay Smiley; Sarah Marzec; Nitin Ramesh Wadhwani; Arthur J DiPatri; Tadanori Tomita; Rishi R. Lulla

doi:10.1097/MPH.0000000000001092

Primary central nervous system malignant melanoma in children: A case series and review of the literature

Daniel K. Choi^*, Natasha Pillay Smiley, Sarah Marzec, Nitin Ramesh Wadhwani, Arthur J DiPatri, Tadanori Tomita, Rishi R. Lulla

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.

Original language	English (US)
Pages (from-to)	616-619
Number of pages	4
Journal	Journal of pediatric hematology/oncology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1097/MPH.0000000000001092
State	Published - Nov 1 2018

Keywords

Central nervous system malignant melanoma
Melanoma
Pediatric brain tumor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000001092

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title = "Primary central nervous system malignant melanoma in children: A case series and review of the literature",

abstract = "We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.",

keywords = "Central nervous system malignant melanoma, Melanoma, Pediatric brain tumor",

author = "Choi, {Daniel K.} and {Pillay Smiley}, Natasha and Sarah Marzec and Wadhwani, {Nitin Ramesh} and DiPatri, {Arthur J} and Tadanori Tomita and Lulla, {Rishi R.}",

year = "2018",

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doi = "10.1097/MPH.0000000000001092",

language = "English (US)",

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Primary central nervous system malignant melanoma in children : A case series and review of the literature. / Choi, Daniel K.; Pillay Smiley, Natasha; Marzec, Sarah; Wadhwani, Nitin Ramesh ; DiPatri, Arthur J ; Tomita, Tadanori; Lulla, Rishi R.

In: Journal of pediatric hematology/oncology, Vol. 40, No. 8, 01.11.2018, p. 616-619.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Primary central nervous system malignant melanoma in children

T2 - A case series and review of the literature

AU - Choi, Daniel K.

AU - Pillay Smiley, Natasha

AU - Marzec, Sarah

AU - Wadhwani, Nitin Ramesh

AU - DiPatri, Arthur J

AU - Tomita, Tadanori

AU - Lulla, Rishi R.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.

AB - We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare tumor in children. Both patients presented with focal neurologic symptoms, with no evidence of skin or other organ system involvement. One patient was treated with temozolomide and etoposide, whereas the other was treated with multiple surgical resections, radiation therapy, and a trial of ipilimumab. New molecularly targeted and immune-based therapies used in metastatic melanoma in adults are potential new treatment options, but their efficacy and safety in pediatric patients needs to be established.

KW - Central nervous system malignant melanoma

KW - Melanoma

KW - Pediatric brain tumor

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JO - Journal of Pediatric Hematology/Oncology

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Primary central nervous system malignant melanoma in children: A case series and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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