Primary Cilia in the Developing and Mature Brain

Alicia Guemez-Gamboa, Nicole G. Coufal, Joseph G. Gleeson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations

Abstract

Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin, the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of little consequence to cellular function. Fast forward 10 years and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and cellular polarity, which regulate neuronal cell fate, migration, differentiation, as well as a host of adult behaviors. Important future questions will focus on structure-function relationships, their roles in signaling and disease and as areas of target for treatments.

Original languageEnglish (US)
Pages (from-to)511-521
Number of pages11
JournalNeuron
Volume82
Issue number3
DOIs
StatePublished - May 7 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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