Primary Cilia in the Developing and Mature Brain

Alicia Guemez-Gamboa; Nicole G. Coufal; Joseph G. Gleeson

doi:10.1016/j.neuron.2014.04.024

Primary Cilia in the Developing and Mature Brain

Alicia Guemez-Gamboa, Nicole G. Coufal, Joseph G. Gleeson^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Review article › peer-review

204 Scopus citations

Abstract

Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin, the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of little consequence to cellular function. Fast forward 10 years and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and cellular polarity, which regulate neuronal cell fate, migration, differentiation, as well as a host of adult behaviors. Important future questions will focus on structure-function relationships, their roles in signaling and disease and as areas of target for treatments.

Original language	English (US)
Pages (from-to)	511-521
Number of pages	11
Journal	Neuron
Volume	82
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2014.04.024
State	Published - May 7 2014

Funding

We wish to thank members of the J.G.G. lab for discussions and Eva Anton, Bradley Yoder, John Wallingford, Val Sheffield, and Peter Jackson for comments. A.G.-G. is supported by a UC MEXUS-CONACYT postdoctoral fellowship.

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2014.04.024

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abstract = "Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin, the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of little consequence to cellular function. Fast forward 10 years and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and cellular polarity, which regulate neuronal cell fate, migration, differentiation, as well as a host of adult behaviors. Important future questions will focus on structure-function relationships, their roles in signaling and disease and as areas of target for treatments.",

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Primary Cilia in the Developing and Mature Brain

Abstract

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