Abstract
Mammary analog secretory carcinoma (MASC) is a recently described tumor of the salivary glands named for its morphological and molecular similarity to secretory carcinoma of the breast. Many primary carcinomas arising from the adnexal glands also share similar morphology to those arising from the breast. Brandt et al first described primary cutaneous MASC in 2009 and since then only 2 other cases have been reported. Herein, we describe a long-standing mass on the arm of an otherwise healthy 40-year-old female. Histologic examination revealed a circumscribed but unencapsulated, nodular tumor composed of bland epithelial cells arranged in solid and microcystic growth patterns. The cells showed vacuolated cytoplasm and round to oval nuclei with vesicular chromatin. Intraluminal homogenous eosinophilic secretions were present. Mitotic figures were not identified. The tumor cells stained positive for CK8/18, CK7, and S100 but were negative for other markers performed, including estrogen receptor, progesterone receptor, HER2/neu, paired box 8 (PAX8), and thyroid transcription factor 1 (TTF1). As the patient clinically had no other masses or known carcinomas, a diagnosis of primary cutaneous MASC was rendered. The ETV6-NTRK3 fusion transcript was subsequently detected by reverse transcriptase polymerase chain reaction amplification, further supporting the diagnosis. We present this case to review the histologic features of MASC and highlight the importance of recognizing this lesion not only as a possible cutaneous metastasis but also as a primary cutaneous tumor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 842-845 |
| Number of pages | 4 |
| Journal | American Journal of Dermatopathology |
| Volume | 38 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2016 |
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Keywords
- ETV6-NTRK3 fusion
- adnexal
- cutaneous mammary analog secretory carcinoma
- mammary analog secretory carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology
Cite this
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Primary cutaneous mammary analog secretory carcinoma with ETV6-NTRK3 translocation. / Amin, Sapna M.; Beattie, Adam; Ling, Xia; Jennings, Lawrence J; Guitart, Joan.
In: American Journal of Dermatopathology, Vol. 38, No. 11, 01.11.2016, p. 842-845.Research output: Contribution to journal › Article
TY - JOUR
T1 - Primary cutaneous mammary analog secretory carcinoma with ETV6-NTRK3 translocation
AU - Amin, Sapna M.
AU - Beattie, Adam
AU - Ling, Xia
AU - Jennings, Lawrence J
AU - Guitart, Joan
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Mammary analog secretory carcinoma (MASC) is a recently described tumor of the salivary glands named for its morphological and molecular similarity to secretory carcinoma of the breast. Many primary carcinomas arising from the adnexal glands also share similar morphology to those arising from the breast. Brandt et al first described primary cutaneous MASC in 2009 and since then only 2 other cases have been reported. Herein, we describe a long-standing mass on the arm of an otherwise healthy 40-year-old female. Histologic examination revealed a circumscribed but unencapsulated, nodular tumor composed of bland epithelial cells arranged in solid and microcystic growth patterns. The cells showed vacuolated cytoplasm and round to oval nuclei with vesicular chromatin. Intraluminal homogenous eosinophilic secretions were present. Mitotic figures were not identified. The tumor cells stained positive for CK8/18, CK7, and S100 but were negative for other markers performed, including estrogen receptor, progesterone receptor, HER2/neu, paired box 8 (PAX8), and thyroid transcription factor 1 (TTF1). As the patient clinically had no other masses or known carcinomas, a diagnosis of primary cutaneous MASC was rendered. The ETV6-NTRK3 fusion transcript was subsequently detected by reverse transcriptase polymerase chain reaction amplification, further supporting the diagnosis. We present this case to review the histologic features of MASC and highlight the importance of recognizing this lesion not only as a possible cutaneous metastasis but also as a primary cutaneous tumor.
AB - Mammary analog secretory carcinoma (MASC) is a recently described tumor of the salivary glands named for its morphological and molecular similarity to secretory carcinoma of the breast. Many primary carcinomas arising from the adnexal glands also share similar morphology to those arising from the breast. Brandt et al first described primary cutaneous MASC in 2009 and since then only 2 other cases have been reported. Herein, we describe a long-standing mass on the arm of an otherwise healthy 40-year-old female. Histologic examination revealed a circumscribed but unencapsulated, nodular tumor composed of bland epithelial cells arranged in solid and microcystic growth patterns. The cells showed vacuolated cytoplasm and round to oval nuclei with vesicular chromatin. Intraluminal homogenous eosinophilic secretions were present. Mitotic figures were not identified. The tumor cells stained positive for CK8/18, CK7, and S100 but were negative for other markers performed, including estrogen receptor, progesterone receptor, HER2/neu, paired box 8 (PAX8), and thyroid transcription factor 1 (TTF1). As the patient clinically had no other masses or known carcinomas, a diagnosis of primary cutaneous MASC was rendered. The ETV6-NTRK3 fusion transcript was subsequently detected by reverse transcriptase polymerase chain reaction amplification, further supporting the diagnosis. We present this case to review the histologic features of MASC and highlight the importance of recognizing this lesion not only as a possible cutaneous metastasis but also as a primary cutaneous tumor.
KW - ETV6-NTRK3 fusion
KW - adnexal
KW - cutaneous mammary analog secretory carcinoma
KW - mammary analog secretory carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84992130239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992130239&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000000590
DO - 10.1097/DAD.0000000000000590
M3 - Article
C2 - 27763904
AN - SCOPUS:84992130239
VL - 38
SP - 842
EP - 845
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 11
ER -