Primary cutaneous T-cell lymphomas: A review

Konstantinos G. Sidiropoulos, M. Estela Martinez-Escala, Oriol Yelamos, Joan Guitart, Michael Sidiropoulos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Primary cutaneous T-cell lymphomas (CTCLs) represent a number of extranodal lymphomas arising from a malignant population of lymphocytes in the skin, with the most common type being mycosis fungoides (MF) representing half of all primary CTCLs. Despite advances in immunohistochemistry and molecular methodology, significant diagnostic challenges remain due to phenotypic overlap of primary CTCLs with several inflammatory dermatoses, secondary lymphomas, among other conditions. Clinical features such as presentation and morphology, staging, histology, immunophenotype and molecular features must be considered in detail before a diagnosis is made in order to minimise falsepositive, false-negative and indeterminate diagnoses. Herein, we review primary CTCLs, including epidemiological data, a brief summary of clinical presentations, immunophenotype, molecular signatures and differential diagnoses.

Original languageEnglish (US)
Pages (from-to)1003-1010
Number of pages8
JournalJournal of Clinical Pathology
Issue number12
StatePublished - Dec 2015

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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