Primary gastric T cell lymphoma mimicking marginal zone B cell lymphoma of mucosa-associated lymphoid tissue

Danniele Holanda, Merry Y. Zhao, Aaron P. Rapoport, Michael Garofalo, Qing Chen, X. Frank Zhao*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Primary gastric T cell lymphoma is rare and mostly of large cell type. In this paper, we present a case of gastric T cell lymphoma morphologically similar to the gastric marginal zone B cell lymphoma of mucosaassociated lymphoid tissue (MALT). Morphologically, the cells are small with abundant clear cytoplasm. Lymphoepithelial lesions are readily identified with diffuse destruction of gastric glands. Immunohistochemically, the neoplastic cells are CD3+/CD4+/CD8-/Granzyme B-. Molecular studies revealed monoclonal T cell receptor γ gene rearrangement. Clinically, the patient responded initially to four cycles of R-CHOP, but then progressed. Because peripheral T cell lymphoma is usually associated with a poor prognosis, whereas marginal zone B cell lymphoma is an indolent lymphoproliferative disorder, this morphologic mimicry should be recognized and completely investigated when atypical small lymphoid infiltrates with lymphoepithelial lesions are encountered in the stomach.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalJournal of Hematopathology
Volume1
Issue number1
DOIs
StatePublished - May 20 2008

Keywords

  • H Pylori
  • HTLV-1
  • Primary gastric Tcell lymphoma.MALT

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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