Primary gastrointestinal sarcomas: Analysis of prognostic factors and results of surgical management

Katharine A. Yao, Mark S. Talamonti*, Rosa L. Langella, Nancy M. Schindler, Sambasiva Rao Musunuri, William Small, Raymond J. Joehl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Background. This study was done to review the clinical presentation, surgical management, and prognostic factors for primary gastrointestinal sarcomas. Methods. We reviewed medical records of 55 patients who were treated for primary gastrointestinal sarcomas from 1981 through 1996. Mean follow-up time was 32 months. Results. Clinical findings included gastrointestinal bleeding (51%), palpable mass (36%), and abdominal pain (33%). The stomach was the most common site of disease (53%), followed by the small intestine (33%). Tumors were high grade in 76% of patients and low-grade in 24% of patients. Complete resection of all gross disease was accomplished in 35 patients (64%), incomplete resection in 17 patients (31%), and biopsy only in 3 patients (5%). Adjacent organ resection was required in 19 patients (35%). Overall actuarial survival was 22% (median survival, 32 months). Unfavorable prognostic factors were incomplete resection, high-grade histologic features, and tumor size of 5 cm or more (P < .05). En bloc resection of contiguous organs did not adversely effect survival. In patients with complete resections, tumor grade was the most important prognostic factor (median survival, 55 months vs 19 months for low-grade vs high-grade tumors; P < .05). Conclusions. Aggressive surgical resection, including en bloc resection of locally advanced tumors, appears warranted. Despite complete resections, patients with high-grade tumors remain at risk for recurrence.

Original languageEnglish (US)
Pages (from-to)604-612
Number of pages9
Issue number4
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Surgery

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