Primary HPV-Associated Enteric-Type Adenocarcinoma of Vagina: A Case Report

Christopher Felicelli, Amanda Strickland, Jian Jun Wei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Primary enteric type adenocarcinomas of the vagina are extremely rare. We present a 63-year-old woman who had a polypoid mass localized to the distal vagina. The lesion was composed of a columnar glandular cell proliferation with focal cribriforming, reminiscent of tubular adenoma. Immunohistochemical stains were notable for expression of enteric markers (CDX2 and KRT20), as well as negativity for Mullerian markers (PAX8, ER, and PR), diffuse expression for p16, and positivity for high-risk HPV mRNA expression. Ultimately, a diagnosis of vaginal primary HPV-associated enteric type adenocarcinoma was rendered for this unusual lesion. To our knowledge, no prior cases of HPV-associated enteric type adenocarcinomas of the vagina have been described before.

Original languageEnglish (US)
Pages (from-to)1393-1397
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume31
Issue number7
DOIs
StatePublished - Oct 2023

Keywords

  • HPV
  • Vagina
  • adenocarcinoma

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine

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