Primary hyperaldosteronism: Effect of adrenal vein sampling on surgical outcome

Fiemu E. Nwariaku*, Barbra S. Miller, Richard Auchus, Shelby Holt, Lori Watumull, Bart Dolmatch, Shawna Nesbitt, Wanpen Vongpatanasin, Ronald Victor, Frank Wians, Edward Livingston, William H. Snyder, Melanie Richards, Clive S. Grant, Quan Yang Duh, Samuel Snyder, Cord Sturgeon, Thomas Biehl

*Corresponding author for this work

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Hypothesis: Adrenal vein sampling is superior to computed tomography for subtype differentiation of primary hyperaldosteronism. Design: Retrospective review. Setting: University medical center. Patients: Forty-eight patients (32 men and 16 women) with biochemically confirmed primary hyperaldosteronism. Main Outcome Measures: We compared demographic factors, results of biochemical and imaging studies (computed tomography and adrenal vein sampling), therapy, and patient outcomes. Results: Mean±SEM adrenal nodule size was 1.54±0.2 cm. Adrenal vein sampling was performed in 41 (85%) of 48 patients, and it was successful in 39 (95%) of those 41 patients. Concordance between computed tomography and adrenal vein sampling was observed in 22 (54%) of the 41 patients. Thirty-two patients underwent successful laparoscopic adrenalectomy. There was 1 complication and no deaths. All 32 patients were cured of hypokalemia. Conclusion: Adrenal vein sampling is superior to image-based techniques for subtype differentiation of primary hyperaldosteronism.

Original languageEnglish (US)
Pages (from-to)497-503
Number of pages7
JournalArchives of Surgery
Volume141
Issue number5
DOIs
StatePublished - May 1 2006

ASJC Scopus subject areas

  • Surgery

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    Nwariaku, F. E., Miller, B. S., Auchus, R., Holt, S., Watumull, L., Dolmatch, B., Nesbitt, S., Vongpatanasin, W., Victor, R., Wians, F., Livingston, E., Snyder, W. H., Richards, M., Grant, C. S., Duh, Q. Y., Snyder, S., Sturgeon, C., & Biehl, T. (2006). Primary hyperaldosteronism: Effect of adrenal vein sampling on surgical outcome. Archives of Surgery, 141(5), 497-503. https://doi.org/10.1001/archsurg.141.5.497