Primary hyperparathyroidism

Clare O’Connor, Joshua A. Levine, Allison J Hahr

Research output: Chapter in Book/Report/Conference proceedingChapter


A 22-year-old man presented to the endocrine clinic for evaluation of presumed polyostotic fibrous dysplasia that had been previously diagnosed at a different hospital. He had a history of a motor vehicle accident at age 15 that led to discovery of a lesion on his left humerus. This lesion was subsequently removed with diagnosis of fibrous dysplasia as per histopathology report. He then had femoral epiphysis slipping requiring bilateral stabilization with screws as well as multiple fractures of his left clavicle, ribs, and right wrist over several years. Imaging had shown multiple sclerotic lesions in his calvarium. He reported chronic polydipsia/polyuria and fluctuating mood due to his chronic bone pain. Review of systems was otherwise negative for headache, weight loss/gain, abdominal pain, nausea, constipation/diarrhea, edema, or skin lesions. There was no reported family history of endocrine disorders.

Original languageEnglish (US)
Title of host publicationMetabolic Bone Diseases
Subtitle of host publicationA Case-Based Approach
PublisherSpringer International Publishing
Number of pages11
ISBN (Electronic)9783030036942
ISBN (Print)9783030036935
StatePublished - Jan 1 2019


  • Hypercalciuria
  • Osteitis fibrosa cystic
  • Primary hyperparathyroidism
  • Vitamin D deficiency

ASJC Scopus subject areas

  • General Medicine


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