Primary mediastinal large B-cell lymphoma in HIV: Report of two cases

Katalin Kelemen*, Wendy Cao, Lo Ann C. Peterson, Andrew M. Evens, Daina Variakojis

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Primary mediastinal large B cell lymphoma (PMLBCL) is a subtype of diffuse large B cell lymphoma arising in the mediastinum with distinctive clinical and morphological features. Though diffuse large B cell lymphoma is one of the most common non-Hodgkin lymphoma associated with AIDS, there are no data available regarding the association of HIV and PMLBCL. We report here two cases of PMLBCL arising in AIDS patients. In both cases, PMLBCL presented in a setting of low CD4 T-cell count as rapidly enlarging mediastinal mass. The morphologic and immunophenotypic findings are characteristic of PMLBCL. One of the two patients, a 25-year-old woman who had localized disease and evidence of Epstein-Barr virus in lymphoma cells, did not respond to chemotherapy and died of disease progression 5 months after diagnosis. The second patient, a 38-year-old male with disseminated disease, responded to therapy and is diseasefree after 9 months of follow-up.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Hematopathology
Volume2
Issue number1
DOIs
StatePublished - Dec 1 2009

Keywords

  • EBV
  • HIV
  • Primary Mediastinal Large B Cell Lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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