TY - JOUR
T1 - Primary nephrotic syndrome of childhood
AU - Schnaper, H. William
PY - 1996
Y1 - 1996
N2 - Primary nephrotic syndrome encompasses the spectrum of minimal change disease, focal segmental glomerulosclerosis, and related disorders. It is a common cause of morbidity and, more rarely, of mortality in children. Recent progress has premitted us to better understand the mechanism of proteinuria and how it causes the other findings of nephrotic. Developments related to the pathogenesis of nephrosis and why some patients develop focal segmental glomerulosclerosis are less striking, but recent studies have indicated useful directions for subsequent work in these areas. Finally, application of newer concepts to treatment has provided both a better prognosis for these diseases and decreased morbidity from treatment.
AB - Primary nephrotic syndrome encompasses the spectrum of minimal change disease, focal segmental glomerulosclerosis, and related disorders. It is a common cause of morbidity and, more rarely, of mortality in children. Recent progress has premitted us to better understand the mechanism of proteinuria and how it causes the other findings of nephrotic. Developments related to the pathogenesis of nephrosis and why some patients develop focal segmental glomerulosclerosis are less striking, but recent studies have indicated useful directions for subsequent work in these areas. Finally, application of newer concepts to treatment has provided both a better prognosis for these diseases and decreased morbidity from treatment.
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U2 - 10.1097/00008480-199604000-00010
DO - 10.1097/00008480-199604000-00010
M3 - Review article
C2 - 8723808
AN - SCOPUS:0029923245
VL - 8
SP - 141
EP - 147
JO - Current Opinion in Pediatrics
JF - Current Opinion in Pediatrics
SN - 1040-8703
IS - 2
ER -