Primary peritoneal serous carcinoma presenting as inflammatory breast cancer

Ibrahim Khalifeh, Michael T. Deavers, Massimo Cristofanilli, Robert L. Coleman, Anais Malpica, Michael Z. Gilcrease

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Metastasis to the breast from extramammary malignancies is rare. Nevertheless, its recognition is important because the prognosis and treatment differ from that of primary breast cancer. We report a unique case of primary peritoneal serous carcinoma that initially presented as inflammatory breast cancer. The patient received neoadjuvant chemotherapy for breast cancer and subsequently underwent bilateral total mastectomy and bilateral sentinel lymph node biopsy. She was found to have extensive intralymphatic carcinoma in both breasts, with only focal minimal breast parenchymal involvement, and residual metastatic carcinoma in bilateral sentinel lymph nodes. Further work-up revealed pelvic ascites and omental nodularities. The patient underwent laparoscopic bilateral salpingo-oophorectomy, which revealed high-grade serous carcinoma involving both ovaries and fallopian tubes. Molecular testing of tumor from the ovary and axillary lymph node showed an identical pattern of allelic loss, confirming a common origin for both tumors. To our knowledge, this is the first reported case of an extramammary primary malignancy that not only presented as inflammatory breast cancer but also was diagnosed and initially treated as such.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalBreast Journal
Volume15
Issue number2
DOIs
StatePublished - Mar 1 2009

Keywords

  • Breast cancer
  • Inflammatory carcinoma
  • Primary peritoneal
  • Serous carcinoma

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology
  • Surgery

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