Primary prophylaxis in sickle cell disease: is it feasible? Is it effective?

Alexis A. Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.

Fingerprint

Sickle Cell Anemia
Disease Progression
Clinical Trials
Wounds and Injuries

ASJC Scopus subject areas

  • Hematology

Cite this

@article{77110ac4479943dd9199a9d79d5f6e55,
title = "Primary prophylaxis in sickle cell disease: is it feasible? Is it effective?",
abstract = "Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.",
author = "Thompson, {Alexis A.}",
year = "2011",
doi = "10.1182/asheducation-2011.1.434",
language = "English (US)",
volume = "2011",
pages = "434--439",
journal = "Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program",
issn = "1520-4391",
publisher = "American Society of Hematology",

}

TY - JOUR

T1 - Primary prophylaxis in sickle cell disease

T2 - is it feasible? Is it effective?

AU - Thompson, Alexis A.

PY - 2011

Y1 - 2011

N2 - Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.

AB - Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.

UR - http://www.scopus.com/inward/record.url?scp=84859412957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859412957&partnerID=8YFLogxK

U2 - 10.1182/asheducation-2011.1.434

DO - 10.1182/asheducation-2011.1.434

M3 - Review article

C2 - 22160070

AN - SCOPUS:84859412957

VL - 2011

SP - 434

EP - 439

JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program

JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program

SN - 1520-4391

ER -