Primary prophylaxis in sickle cell disease: is it feasible? Is it effective?

Alexis A. Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Scopus citations


Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalHematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
Publication statusPublished - 2011


ASJC Scopus subject areas

  • Hematology

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