TY - JOUR
T1 - Primary prophylaxis in sickle cell disease
T2 - is it feasible? Is it effective?
AU - Thompson, Alexis A.
PY - 2011
Y1 - 2011
N2 - Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.
AB - Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.
UR - http://www.scopus.com/inward/record.url?scp=84859412957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859412957&partnerID=8YFLogxK
U2 - 10.1182/asheducation-2011.1.434
DO - 10.1182/asheducation-2011.1.434
M3 - Review article
C2 - 22160070
AN - SCOPUS:84859412957
SN - 1520-4391
VL - 2011
SP - 434
EP - 439
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -