Abstract
Understanding the lineage of the diverse neuronal populations of the CNS is a complex but critical task. Poulin et al. present PRISM, an approach that facilitates recombinase-based lineage analysis. Using PRISM, the authors redefined the lineages of key forebrain progenitor populations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 740-753.e3 |
| Journal | Developmental Cell |
| Volume | 53 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 22 2020 |
Funding
The authors wish to acknowledge the help from Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) and support from HBHL/CREF to J.-F.P. NIH R01NS069777 and NIH R01MH112768 to C.S.C. and NIH R21NS092034-01A1 and NIH R01NS096240 to R.A. J.-F.P. and M.P.L. designed and performed experiments, analyzed data, and wrote the manuscript; C.H. performed quantitative analysis; G.C. helped with embryonic forebrain analysis; P.-K.H. helped with transgene design; C.S.C. provided intellectual input on GPe origins and diversity as well as antibody labeling for interneurons; R.A. supervised the study and helped write the manuscript. The authors declare no competing interests. The authors wish to acknowledge the help from Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) and support from HBHL/CREF to J.-F.P., NIH R01NS069777 and NIH R01MH112768 to C.S.C., and NIH R21NS092034-01A1 and NIH R01NS096240 to R.A.
Keywords
- Cux2
- Sonic hedgehog
- development
- fate mapping
- forebrain
- intersectional genetics
- lineage
- neuron
- progenitor
- recombinase
ASJC Scopus subject areas
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- Developmental Biology
- Cell Biology