Probabilistic division systems modeling the generation of mosaic fields

P. M. Iannaccone; L. Berkwits; J. Joglar; J. Lindsay; A. Lunde

doi:10.1016/S0022-5193(89)80119-5

Probabilistic division systems modeling the generation of mosaic fields

P. M. Iannaccone^*, L. Berkwits, J. Joglar, J. Lindsay, A. Lunde

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.

Original language	English (US)
Pages (from-to)	363-366,IN1-IN2,367-374,IN3,375-377
Journal	Journal of Theoretical Biology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5193(89)80119-5
State	Published - Dec 7 1989

Funding

This work was supported in part by USPHS grants CA29078 and SEO3498 from DHHS.

ASJC Scopus subject areas

General Immunology and Microbiology
Applied Mathematics
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Statistics and Probability
Modeling and Simulation

Access to Document

10.1016/S0022-5193(89)80119-5

Cite this

@article{245227f76e964f2badade695f4fcf53d,

title = "Probabilistic division systems modeling the generation of mosaic fields",

abstract = "The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.",

author = "Iannaccone, {P. M.} and L. Berkwits and J. Joglar and J. Lindsay and A. Lunde",

note = "Funding Information: This work was supported in part by USPHS grants CA29078 and SEO3498 from DHHS.",

year = "1989",

month = dec,

day = "7",

doi = "10.1016/S0022-5193(89)80119-5",

language = "English (US)",

volume = "141",

pages = "363--366,IN1--IN2,367--374,IN3,375--377",

journal = "Journal of Theoretical Biology",

issn = "0022-5193",

publisher = "Academic Press",

number = "3",

}

TY - JOUR

T1 - Probabilistic division systems modeling the generation of mosaic fields

AU - Iannaccone, P. M.

AU - Berkwits, L.

AU - Joglar, J.

AU - Lindsay, J.

AU - Lunde, A.

N1 - Funding Information: This work was supported in part by USPHS grants CA29078 and SEO3498 from DHHS.

PY - 1989/12/7

Y1 - 1989/12/7

N2 - The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.

AB - The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.

UR - http://www.scopus.com/inward/record.url?scp=0024843701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024843701&partnerID=8YFLogxK

U2 - 10.1016/S0022-5193(89)80119-5

DO - 10.1016/S0022-5193(89)80119-5

M3 - Article

C2 - 2630795

AN - SCOPUS:0024843701

SN - 0022-5193

VL - 141

SP - 363-366,IN1-IN2,367-374,IN3,375-377

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 3

ER -

Probabilistic division systems modeling the generation of mosaic fields

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this