Probabilistic division systems modeling the generation of mosaic fields

P. M. Iannaccone*, L. Berkwits, J. Joglar, J. Lindsay, A. Lunde

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The explanation of mosaic pattern in chimeric organs analyzed by in situ methods requires modeling of specific hypotheses. The use of computer simulations to achieve this has led to the conclusion that finely variegated mixtures of cell lineage within chimeric tissues does not require extensive cell movement. Cell division models were used to determine the distribution of patch size as mosaic fields are generated. The results establish that these distributions are sensitive to the proportion of the two cell types which comprise the mosaic.

Original languageEnglish (US)
Pages (from-to)363-366,IN1-IN2,367-374,IN3,375-377
JournalJournal of Theoretical Biology
Volume141
Issue number3
DOIs
StatePublished - Dec 7 1989

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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