Probabilistic map of critical functional regions of the human cerebral cortex

Broca's area revisited

Matthew Christopher Tate, Guillaume Herbet, Sylvie Moritz-Gasser, Joseph E. Tate, Hugues Duffau*

*Corresponding author for this work

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The organization of basic functions of the human brain, particularly in the right hemisphere, remains poorly understood. Recent advances in functional neuroimaging have improved our understanding of cortical organization but do not allow for direct interrogation or determination of essential (versus participatory) cortical regions. Direct cortical stimulation represents a unique opportunity to provide novel insights into the functional distribution of critical epicentres. Direct cortical stimulation (bipolar, 60 Hz, 1-ms pulse) was performed in 165 consecutive patients undergoing awake mapping for resection of low-grade gliomas. Tasks included motor, sensory, counting, and picture naming. Stimulation sites eliciting positive (sensory/motor) or negative (speech arrest, dysarthria, anomia, phonological and semantic paraphasias) findings were recorded and mapped onto a standard Montreal Neurological Institute brain atlas. Montreal Neurological Institute-space functional data were subjected to cluster analysis algorithms (K-means, partition around medioids, hierarchical Ward) to elucidate crucial network epicentres. Sensorimotor function was observed in the pre/post-central gyri as expected. Articulation epicentres were also found within the pre/post-central gyri. However, speech arrest localized to ventral premotor cortex, not the classical Broca's area. Anomia/ paraphasia data demonstrated foci not only within classical Wernicke's area but also within the middle and inferior frontal gyri. We report the first bilateral probabilistic map for crucial cortical epicentres of human brain functions in the right and left hemispheres, including sensory, motor, and language (speech, articulation, phonology and semantics). These data challenge classical theories of brain organization (e.g. Broca's area as speech output region) and provide a distributed framework for future studies of neural networks.

Original languageEnglish (US)
Pages (from-to)2773-2782
Number of pages10
JournalBrain
Volume137
Issue number10
DOIs
StatePublished - Jan 1 2014

Fingerprint

Cerebral Cortex
Anomia
Somatosensory Cortex
Brain
Semantics
Organizations
Dysarthria
Functional Neuroimaging
Atlases
Motor Cortex
Prefrontal Cortex
Glioma
Cluster Analysis
Language
Broca Area

Keywords

  • Brain mapping
  • Broca's area
  • Direct cortical electrostimulation
  • Language
  • Probabilistic map

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Tate, Matthew Christopher ; Herbet, Guillaume ; Moritz-Gasser, Sylvie ; Tate, Joseph E. ; Duffau, Hugues. / Probabilistic map of critical functional regions of the human cerebral cortex : Broca's area revisited. In: Brain. 2014 ; Vol. 137, No. 10. pp. 2773-2782.
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Probabilistic map of critical functional regions of the human cerebral cortex : Broca's area revisited. / Tate, Matthew Christopher; Herbet, Guillaume; Moritz-Gasser, Sylvie; Tate, Joseph E.; Duffau, Hugues.

In: Brain, Vol. 137, No. 10, 01.01.2014, p. 2773-2782.

Research output: Contribution to journalArticle

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