Probing chromosome structure with dynamic force relaxation

Michael G. Poirier, Ajay Nemani, Prateek Gupta, Sertac Eroglu, John F. Marko

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.

Original languageEnglish (US)
Pages (from-to)360-363
Number of pages4
JournalPhysical review letters
Volume86
Issue number2
DOIs
StatePublished - Jan 8 2001

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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