Probing chromosome structure with dynamic force relaxation

Michael G. Poirier; Ajay Nemani; Prateek Gupta; Sertac Eroglu; John F. Marko

doi:10.1103/PhysRevLett.86.360

Probing chromosome structure with dynamic force relaxation

Michael G. Poirier, Ajay Nemani, Prateek Gupta, Sertac Eroglu, John F. Marko

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.

Original language	English (US)
Pages (from-to)	360-363
Number of pages	4
Journal	Physical review letters
Volume	86
Issue number	2
DOIs	https://doi.org/10.1103/PhysRevLett.86.360
State	Published - Jan 8 2001

ASJC Scopus subject areas

General Physics and Astronomy

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10.1103/PhysRevLett.86.360

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title = "Probing chromosome structure with dynamic force relaxation",

abstract = "Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.",

author = "Poirier, \{Michael G.\} and Ajay Nemani and Prateek Gupta and Sertac Eroglu and Marko, \{John F.\}",

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AU - Gupta, Prateek

AU - Eroglu, Sertac

AU - Marko, John F.

PY - 2001/1/8

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N2 - Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.

AB - Chromosomes from new epithelial cells (TVI cell line) grown in a monolayer on a small dish were microdissected. The dynamics of stress relaxation in the microdissected chromosomes was characterized. It was found that mitotic chromosomes quickly stretched display well-defined elastic response with a relaxation time on the second time scale. Further, it was observed that loose loop domains are present in physiological conditions.

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Probing chromosome structure with dynamic force relaxation

Abstract

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