Probing selectivity in recognition-mediated dynamic covalent processes

Raphael M. Bennes, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Two simple recognition-mediated dynamic Diels-Alder systems are used to probe the role of kinetics and thermodynamics in determining the equilibrium position in exchanging libraries and the time taken to reach that equilibrium. The selectivity expressed by recognition-driven dynamic processes is demonstrated to be less than the free-energy difference between the components as a result of compensatory effects arising from the extent of conversion to products within the library.

Original languageEnglish (US)
Pages (from-to)3651-3654
Number of pages4
JournalOrganic Letters
Volume8
Issue number17
DOIs
StatePublished - Aug 17 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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