Probing structural effects on replication efficiency through comparative analyses of families of potential self-replicators

Eleftherios Kassianidis, Russell J. Pearson, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship be tween molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.

Original languageEnglish (US)
Pages (from-to)8798-8812
Number of pages15
JournalChemistry - A European Journal
Volume12
Issue number34
DOIs
StatePublished - Nov 24 2006

Keywords

  • Kinetics
  • Molecular recognition
  • Recognition-mediated reactions
  • Self-replication
  • Supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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