Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: Comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2′-O-ribonucleic acid modifications

Martin Egli^*, George Minasov, Valentina Tereshko, Pradeep S. Pallan, Marianna Teplova, Gopal B. Inamati, Elena A. Lesnik, Steve R. Owens, Bruce S. Ross, Thazha P. Prakash, Muthiah Manoharan

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

11 results
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Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(N,N-dimethylaminooxy)ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1YB9/pdb, https://www.wwpdb.org/pdb?id=pdb_00001yb9
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-allyl Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y9F/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y9f
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-propargyl Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y9S/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y9s
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(trifluoro)ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y8L/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y8l
Dataset
X-ray structure of the A-decamer GCGTATACGC with a single 2'-O-butyl thymine in place of T6, Sr-form
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1WV6/pdb, https://www.wwpdb.org/pdb?id=pdb_00001wv6
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(fluoro)ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y86/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y86
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(benzyloxy)ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1YBC/pdb, https://www.wwpdb.org/pdb?id=pdb_00001ybc
Dataset
X-ray structure of the A-decamer GCGTATACGC with a single 2'-o-butyl thymine in place of T6, Mg-form
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1WV5/pdb, https://www.wwpdb.org/pdb?id=pdb_00001wv5
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-propyl Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y8V/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y8v
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-(imidazolyl)ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y84/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y84
Dataset
Crystal structure of the A-DNA GCGTAT*CGC with a 2'-O-[2-[hydroxy(methyleneamino)oxy]ethyl] Thymidine (T*)
Egli, M. (Contributor), Minasov, G. (Contributor), Tereshko, V. (Contributor), Pallan, P. S. (Contributor), Teplova, M. (Contributor), Inamati, G. B. (Contributor), Lesnik, E. A. (Contributor), Owens, S. R. (Contributor), Ross, B. S. (Contributor), Prakash, T. P. (Contributor) & Manoharan, M. (Contributor), Protein Data Bank (PDB), Jun 28 2005
DOI: 10.2210/pdb1Y7F/pdb, https://www.wwpdb.org/pdb?id=pdb_00001y7f
Dataset

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: Comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2′-O-ribonucleic acid modifications

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-(N,N-dimethylaminooxy)ethyl] Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-allyl Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-propargyl Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-(trifluoro)ethyl] Thymidine (T)

X-ray structure of the A-decamer GCGTATACGC with a single 2'-O-butyl thymine in place of T6, Sr-form

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-(fluoro)ethyl] Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-(benzyloxy)ethyl] Thymidine (T)

X-ray structure of the A-decamer GCGTATACGC with a single 2'-o-butyl thymine in place of T6, Mg-form

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-propyl Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-(imidazolyl)ethyl] Thymidine (T)

Crystal structure of the A-DNA GCGTATCGC with a 2'-O-[2-[hydroxy(methyleneamino)oxy]ethyl] Thymidine (T)

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: Comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2′-O-ribonucleic acid modifications

Datasets

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