Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library

Tamara Kosikova; Harry MacKenzie; Douglas Philp

doi:10.1002/chem.201503740

Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library

Tamara Kosikova, Harry MacKenzie, Douglas Philp^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Two recognition-mediated reaction processes operating through reactive binary complexes drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and the strength of the recognition processes employed in the dynamic system.

Original language	English (US)
Pages (from-to)	1831-1839
Number of pages	9
Journal	Chemistry - A European Journal
Volume	22
Issue number	5
DOIs	https://doi.org/10.1002/chem.201503740
State	Published - Jan 26 2016

Keywords

NMR spectroscopy
combinatorial chemistry
cycloaddition reaction
kinetics
molecular recognition

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/chem.201503740

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abstract = "Two recognition-mediated reaction processes operating through reactive binary complexes drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and the strength of the recognition processes employed in the dynamic system.",

keywords = "NMR spectroscopy, combinatorial chemistry, cycloaddition reaction, kinetics, molecular recognition",

author = "Tamara Kosikova and Harry MacKenzie and Douglas Philp",

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Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library

Abstract

Keywords

ASJC Scopus subject areas

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