Probing the Limits of Selectivity in a Recognition-Mediated Reaction Network Embedded within a Dynamic Covalent Library

Tamara Kosikova, Harry MacKenzie, Douglas Philp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Two recognition-mediated reaction processes operating through reactive binary complexes drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and the strength of the recognition processes employed in the dynamic system.

Original languageEnglish (US)
Pages (from-to)1831-1839
Number of pages9
JournalChemistry - A European Journal
Volume22
Issue number5
DOIs
StatePublished - Jan 26 2016

Keywords

  • NMR spectroscopy
  • combinatorial chemistry
  • cycloaddition reaction
  • kinetics
  • molecular recognition

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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