Probiotics and prevention of Clostridium difficile infection

E. J.C. Goldstein; S. J. Johnson; P. J. Maziade; C. T. Evans; J. C. Sniffen; M. Millette; L. V. McFarland

doi:10.1016/j.anaerobe.2016.12.007

Probiotics and prevention of Clostridium difficile infection

E. J.C. Goldstein^*, S. J. Johnson, P. J. Maziade, C. T. Evans, J. C. Sniffen, M. Millette, L. V. McFarland

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The role of probiotics as adjunctive measures in the prevention of Clostridium difficile infection (CDI) has been controversial. However, a growing body of evidence has suggested that they have a role in primary prevention of CDI. Elements of this controversy are reviewed and the proposed mechanisms of action, the value and cost effectiveness of probiotics are addressed with a focus on three agents, Saccharomyces boulardii, Lactobacillus rhamnosus GG and the combination of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, Lactobacillus rhamnosus CLR2 (Bio-K+).

Original language	English (US)
Pages (from-to)	114-119
Number of pages	6
Journal	Anaerobe
Volume	45
DOIs	https://doi.org/10.1016/j.anaerobe.2016.12.007
State	Published - Jun 2017

Keywords

Bio-K+
C. difficile
Lactobacillus acidophilus CL1285
Lactobacillus casei LBC80R
Lactobacillus rhamnosus CLR2
Lactobacillus rhamnosus GG
Probiotic
Saccharomyces boulardii

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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title = "Probiotics and prevention of Clostridium difficile infection",

abstract = "The role of probiotics as adjunctive measures in the prevention of Clostridium difficile infection (CDI) has been controversial. However, a growing body of evidence has suggested that they have a role in primary prevention of CDI. Elements of this controversy are reviewed and the proposed mechanisms of action, the value and cost effectiveness of probiotics are addressed with a focus on three agents, Saccharomyces boulardii, Lactobacillus rhamnosus GG and the combination of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, Lactobacillus rhamnosus CLR2 (Bio-K+).",

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author = "Goldstein, {E. J.C.} and Johnson, {S. J.} and Maziade, {P. J.} and Evans, {C. T.} and Sniffen, {J. C.} and M. Millette and McFarland, {L. V.}",

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AU - Johnson, S. J.

AU - Maziade, P. J.

AU - Evans, C. T.

AU - Sniffen, J. C.

AU - Millette, M.

AU - McFarland, L. V.

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