Problems in Classification of schizophrenics as Neuroleptic Responders and Nonresponders

J. G. Csernansky, J. Kaplan, L. E. Hollister

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The authors review the many clinical and pharmacological factors that affect neuroleptic response and complicate the classification of schizophrenic patients into responders and nonresponders. The subtyping of patients on the basis of “positive” or “negative” symptoms and the presence or absence of brain atrophy may be particularly useful in predicting neuroleptic response. There is also a promising relationship between plasma neuroleptic concentrations and response. The concept of supersensitivity psychosis is introduced as a reason for apparent nonresponse in some patients. In others, neuroleptic responsivity may be inherently variable. The authors make suggestions for future research in neuroleptic response.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalJournal of Nervous and Mental Disease
Issue number6
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Psychiatry and Mental health


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