Procedures for risk-stratification of lung cancer using Buccal Nanocytology

H. Subramanian, P. Viswanathan, L. Cherkezyan, R. Iyengar, S. Rozhok, M. Verleye, J. Derbas, J. Czarnecki, H. K. Roy, V. Backman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians’ office.

Original languageEnglish (US)
Article number#268778
Pages (from-to)3795-3810
Number of pages16
JournalBiomedical Optics Express
Volume7
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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