TY - JOUR
T1 - Procedures for risk-stratification of lung cancer using Buccal Nanocytology
AU - Subramanian, H.
AU - Viswanathan, P.
AU - Cherkezyan, L.
AU - Iyengar, R.
AU - Rozhok, S.
AU - Verleye, M.
AU - Derbas, J.
AU - Czarnecki, J.
AU - Roy, H. K.
AU - Backman, V.
N1 - Funding Information:
The results presented here are based upon the work supported by National Science Foundation Small Business Innovation Research program under Grant IIP-1214989, Grant from LUNGevity Foundation and the National Institutes of Health Small Business Innovation Research Program under Grant 1R44CA168185, the National Institutes of Health under Grants: R01EB016983, R01CA155284. Drs. Subramanian, Backman and Roy are cofounders and/or shareholders in NanoCytomics LLC. All aspects of this study were done under the supervision of the Conflict of Interest Committee at Northwestern University.
Publisher Copyright:
© 2016 Optical Society of America.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians’ office.
AB - Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians’ office.
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U2 - 10.1364/BOE.7.003795
DO - 10.1364/BOE.7.003795
M3 - Article
C2 - 27699138
AN - SCOPUS:84989838958
SN - 2156-7085
VL - 7
SP - 3795
EP - 3810
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 9
M1 - #268778
ER -
