Processing and assembly of the dystrophin glycoprotein complex

Michael J. Allikian*, Elizabeth M. McNally

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations


The assembly, processing and translocation of proteins occur constantly in all cells, and these processes also take place during the genesis, maintenance and repair of skeletal muscle. Skeletal muscle fibers are composed of myofibrils and are surrounded by a muscle plasma membrane, the sarcolemma. The sarcolemma serves as a docking location for many proteins. These proteins are important for establishing the physical connection between the extracellular matrix and the cytoskeleton and play a role in transmitting force related to muscle contraction. This physical connection is maintained through a myriad of proteins including the dystrophin glycoprotein complex (DGC). Normal sarcolemmal function requires proper DGC synthesis and positioning, and perturbation of the DGC leads to muscle membrane instability and disease.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
Issue number3
StatePublished - Mar 2007


  • Dystrophin
  • Muscular dystrophy
  • Sarcoglycan
  • Sarcolemma

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Structural Biology
  • Biochemistry
  • Cell Biology


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