Production of Transgenic Rats

Philip Iannaccone*, Vasiliy Galat

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The procedures for production of transgenic rats, in comparison to transgenic mice, while widely used are less available. The rat is a very important species for the production of animal models of human disease and physiology. In many ways, the rat is model of choice for studies of human disease. There is more than a century of papers published with extensive phenotypic data from the rat. With more than 250 strains of rat which include inbred strains, congenics, mutants, transgenics, and now targeted loss of function mutations, there are important animals available for the study of cardiopulmonary disease and physiology, renal disease, and physiology.

Original languageEnglish (US)
Title of host publicationTransgenic Animal Technology
Subtitle of host publicationA Laboratory Handbook: Third Edition
PublisherElsevier Inc
Pages251-273
Number of pages23
ISBN (Print)9780124104907
DOIs
StatePublished - Jun 23 2014

Keywords

  • Cloning
  • Embryo production
  • Embryo transfer
  • Lentiviral gene transfer
  • Nuclear transfer
  • Rat husbandry
  • Transgenic rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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