The emergence of methicillin-resistant Staphylococcus aureus (MRSA) within the community has altered health care practice because it is a major public health threat and has several important clinical implications. As the incidence of MRSA increases in the community, empirical treatment of community-acquired skin and soft tissue infections and necrotizing pneumonia without obtaining microbiological cultures from the infected site may not be appropriate and can lead to treatment failure if initial therapy includes a β-lactam antibiotic or other agents to which the bacteria is resistant. The Infectious Disease Society of America in their recently published guideline on community-acquired pneumonia recommends that although methicillin-resistant strains of S. aureus are still in the minority, the high mortality associated with inappropriate antibiotic therapy would suggest that empirical coverage should be considered when community-associated MRSA is a concern.
ASJC Scopus subject areas
- Microbiology (medical)